Results 71 to 80 of about 1,875,662 (355)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Journal of Education and Health Promotion, 2020 INTRODUCTION: The aim of this study was to evaluate the cognitive, psychomotor, and attitudinal readiness of faculty members and students of Shiraz University of Medical Sciences for using e-learning in 2019 in order to move toward the desired future of ...
Parisa Mokaripour +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The moral behavior of ethics professors: A replication-extension in German-speaking countries
Philosophical Psychology, 2019 What is the relation between ethical reflection and moral behavior? Does professional reflection on ethical issues positively impact moral behaviors?
Philipp Schönegger, J. Wagner
semanticscholar +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Вопросы образования, 2015 A lot of potential is held by classifying university research as an individual discipline. Its evolvement is now progressing through conceptualizing the subject field and testing various disciplinary approaches towards describing the university as a ...
Yana Rudneva
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Effect of Influent COD/N Ratio on Nitrification Rate in a Bench-scale Biological Reactor [PDF]
آب و فاضلاب, 2005 Nitrification, the oxidation of ammonia to nitrate catalyzed by bacteria, is a key part of the global nitrogen cycle. In the first step of nitrification, chemolithoautotrophic ammonia oxidizers transform ammonia to nitrite, which subsequently oxidizes to
Bijan Bina +2 more
doaj