Results 61 to 70 of about 227,658 (256)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Investigating the use and acceptance of technologies by professors in a higher education institution [PDF]
, 2019 This article analyses the use and acceptance of technologies by professors in the teaching and learning context in a higher education institution. In the empirical study, a questionnaire based on the technology acceptance model was applied. The results
Teixeira, Leonor +2 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The construction process of pedagogical knowledge among nursing professors [PDF]
, 2011 Didactic knowledge about contents is constructed through an idiosyncratic synthesis between knowledge about the subject area, students' general pedagogical knowledge and the teacher's biography. This study aimed to understand the construction process and
Prado, Marta Lenise do +6 more
core +1 more source
Assessment of Nurses Role as Regarding Care of Patients Undergoing Hemodialysis Therapy [PDF]
Egyptian Journal of Health CareBackground: Nurses play multifaceted role in hemodialysis care, encompassing patient assessment, education, physical and emotional support, and the management of complications.
Samar Ahmed Abdel Rahman Seddik +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Capital budgeting: the Romanian university professors' points of view [PDF]
This study aims at validating the points of view of the Romanian finance university professors regarding capital budgeting. The study is original and important in the same time, taking into consideration that their opinions, due to their vocation of ...
Andreea Semenescu +4 more
core
Outcomes of Patients Receiving Radiofrequency Ablation Therapy for Hepatocellular Carcinoma: Effect of Self-Care Management Guidelines [PDF]
Egyptian Journal of Health CareBackground: Hepatocellular carcinoma is the sixth leading cause of cancer-related deaths worldwide. Self-care practices are crucial for relieving illness symptoms and adverse effects.
Mona Nadr Ebraheim Ahmed +1 more
doaj +1 more source