Results 61 to 70 of about 1,875,662 (355)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Історія науки і техніки, 2021 The article is devoted to the study of the development of the source criticism’s knowledge in the Imperial Novorossiya University which was founded in the second half of the XIX century in Odesa. Grounding on a large complex of general scientific methods,
Irena Grebtsova, Maryna Kovalska
doaj +1 more source
, 2011 When students enter college classrooms for the first time they inevitably have preconceived images of professors. According to research on student evaluations of teaching, these preconceptions have important implications in college classrooms. This study
Dagaz, Mari, Harger, Brent D.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Study of a Mathematical Model of Biocide Effect on a Biofilm Isolated from a Cooling System Using the Microtiter Plate [PDF]
آب و فاضلاب, 2005 Bacterial colonization on metal surfaces and their metabolic activities lead to biocorrosion. In fact, any agent removing the biofilm or decreasing its thickness is capable of preventing biocorrosion. Biocides make up one such agent.
Shahryar Shakeri +2 more
doaj
Exploring Fairness in Online Nursing Assessments: Insights from Nursing Professors and Students [PDF]
Interdisciplinary Journal of Virtual Learning in Medical SciencesBackground: Fairness in online assessment encompasses the equitable and unbiased evaluation of students' knowledge and skills within a digital learning environment, and it is one of the most critical aspects of assessment.
Hootsa Asefi +3 more
doaj +1 more source
Becoming a Scientist: Using First-Year Undergraduate Science Courses to Promote Identification with Science Disciplines [PDF]
, 2016 In this qualitative study, we examined how two professors (a physicist and biochemist) of first year college students perceived their students’ development of identification in biochemistry or physics and how they actively supported this development. The
Jones, Brett D., Ruff, Chloe
core +4 more sources