Results 41 to 50 of about 2,698,368 (301)

Using PyBioNetFit to leverage qualitative and quantitative data in biological model parameterization and uncertainty quantification

Frontiers in Immunology
Data generated in studies of cellular regulatory systems are often qualitative. For example, measurements of signaling readouts in the presence and absence of mutations may reveal a rank ordering of responses across conditions but not the precise extents
Ely F. Miller, Abhishek Mallela, Abhishek Mallela, Jacob Neumann, Yen Ting Lin, Yen Ting Lin, William S. Hlavacek, William S. Hlavacek, Richard G. Posner   +8 more
doaj   +1 more source

Adjustments of profile likelihood through predictive densities

, 2011
Estimative predictive density, Modified profile likelihood, Nuisance parameter, Predictive pivot, Profile likelihood, Second-order asymptotics,
Alessandra Salvan, Pace L., Luigi Pace, SALVAN, ALESSANDRA, Laura Ventura, VENTURA, LAURA   +5 more
core   +1 more source

On interval and point estimators based on a penalization of the modified profile likelihood [PDF]

, 2011
Various modifications of the profile likelihood have been proposed in the literature. Despite modified profile likelihood methods have better properties than those based on the profile likelihood, the signed likelihood ratio statistic based on the ...
W. Racugno, Racugno, Walter, VENTURA, LAURA   +2 more
core   +1 more source

Identifying Risk Profiles of Malignant Prostate Cancer Surgical Delay Using a Person-Centered Approach to Understand Prostate Cancer Disparities: The Constellation of Health Determinants Using Latent Class Analysis on Cancer Registry Data

American Journal of Men's Health, 2020
Surgical prostate cancer (PCa) treatment delay (TD) may increase the likelihood of recurrence of disease, and influence quality of life as well as survival disparities between Black and White men.
Francisco A. Montiel Ishino PhD, MPH, Claire Rowan BS, Rina Das PhD, Janani Thapa PhD, Ewan Cobran PhD, Martin Whiteside PhD MSPH, Faustine Williams PhD, MPH MS   +6 more
doaj   +1 more source

Profiles on Adolescent Internet Addiction: A Taxonomy with Latent Profiling Analysis

Acta Médica Portuguesa, 2022
Introduction: Addictive use of the Internet among adolescents has been linked to a negative psychosocial development, but more detailed information about Internet addiction (IA) profiles is warranted. The aim of this study was to identify IA profiles in
Miguel Vieira Martins, Ricardo Gouveia Rodrigues, Paula Saraiva Carvalho, Sofia Ferreira   +3 more
doaj   +1 more source

Are profile likelihoods likelihoods? No, but sometimes they can be

, 2019
We offer our two cents to the ongoing discussion on whether profile likelihoods are "true" likelihood functions, by showing that the profile likelihood function can in fact be identical to a marginal likelihood in the special case of normal models.
Huang, Alan, Kim, Andy Sangil
openaire   +2 more sources

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Developmental validation of a software implementation of a flexible framework for the assignment of likelihood ratios for forensic investigations

Forensic Science International: Reports, 2021
The developmental validation of the software DBLR™ (‘database likelihood ratios’) is described. DBLR™ implements a flexible framework for the assignment of likelihood ratios for forensic DNA profiles. This framework allows the user to assign a likelihood
Hannah Kelly, Zane Kerr, Kevin Cheng, Maarten Kruijver, Jo-Anne Bright   +4 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source