Results 111 to 120 of about 1,079,892 (278)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Constraint on Lorentz invariance violation for spectral lag transition in GRB 160625B using profile likelihood

European Physical Journal C: Particles and Fields
We reanalyze the spectral lag data for GRB 160625B using frequentist inference in order to constrain the energy scale $$(E_{QG})$$ ( E QG ) of Lorentz Invariance Violation (LIV).
Shantanu Desai, Shalini Ganguly
doaj   +1 more source

Surveillance for endemic infectious disease outbreaks: Adaptive sampling using profile likelihood estimation. [PDF]

Stat Med, 2022
Fairley M, Rao IJ, Brandeau ML, Qian GL, Gonsalves GS.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mixed Non-Parametric and Parametric Estimation Techniques in R Package etasFLP for Earthquakes' Description

Journal of Statistical Software, 2017
etasFLP is an R package which fits an epidemic type aftershock sequence (ETAS) model to an earthquake catalog; non-parametric background seismicity can be estimated through a forward predictive likelihood approach, while parametric components of ...
Marcello Chiodi, Giada Adelfio
doaj   +1 more source

Profile likelihood analysis for a stochastic model of diffusion in heterogeneous media. [PDF]

Proc Math Phys Eng Sci, 2021
Simpson MJ, Browning AP, Drovandi C, Carr EJ, Maclaren OJ, Baker RE.   +5 more
europepmc   +1 more source

Profile Likelihoods on ML-Steroids

Profile likelihoods, for instance, describing global SMEFT analyses at the LHC are numerically expensive to construct and evaluate. Especially profiled likelihoods are notoriously unstable and noisy. We show how modern numerical tools, similar to neural importance sampling, lead to a huge numerical improvement and allow us to evaluate the complete ...
Heimel, Theo, Plehn, Tilman, Schmal, Nikita   +2 more
openaire   +2 more sources

Are profile likelihoods likelihoods? No, but sometimes they can be

, 2019
We offer our two cents to the ongoing discussion on whether profile likelihoods are "true" likelihood functions, by showing that the profile likelihood function can in fact be identical to a marginal likelihood in the special case of normal models.
Huang, Alan, Kim, Andy Sangil
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Profile-likelihood Bayesian model averaging for two-sample summary data Mendelian randomization in the presence of horizontal pleiotropy. [PDF]

Stat Med, 2022
Shapland CY, Zhao Q, Bowden J.
europepmc   +1 more source