Results 131 to 140 of about 4,713,645 (328)

Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton-proton collisions at s=13TeV. [PDF]

open access: yesEur Phys J C Part Fields, 2023
Tumasyan A   +2351 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Profile Likelihoods on ML-Steroids

open access: yes
Profile likelihoods, for instance, describing global SMEFT analyses at the LHC are numerically expensive to construct and evaluate. Especially profiled likelihoods are notoriously unstable and noisy. We show how modern numerical tools, similar to neural importance sampling, lead to a huge numerical improvement and allow us to evaluate the complete ...
Heimel, Theo   +2 more
openaire   +2 more sources

Are profile likelihoods likelihoods? No, but sometimes they can be

open access: yes, 2019
We offer our two cents to the ongoing discussion on whether profile likelihoods are "true" likelihood functions, by showing that the profile likelihood function can in fact be identical to a marginal likelihood in the special case of normal models.
Huang, Alan, Kim, Andy Sangil
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Mixed Non-Parametric and Parametric Estimation Techniques in R Package etasFLP for Earthquakes' Description

open access: yesJournal of Statistical Software, 2017
etasFLP is an R package which fits an epidemic type aftershock sequence (ETAS) model to an earthquake catalog; non-parametric background seismicity can be estimated through a forward predictive likelihood approach, while parametric components of ...
Marcello Chiodi, Giada Adelfio
doaj   +1 more source

Likelihood Functions for State Space Models with Diffuse Initial Conditions [PDF]

open access: yes, 2008
State space models with nonstationary processes and fixed regression effects require a state vector with diffuse initial conditions. Different likelihood functions can be adopted for the estimation of parameters in time series models with diffuse initial
Francke, M.K.   +2 more
core   +4 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

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