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The developmental validation of the software DBLR™ (‘database likelihood ratios’) is described. DBLR™ implements a flexible framework for the assignment of likelihood ratios for forensic DNA profiles. This framework allows the user to assign a likelihood
Hannah Kelly +4 more
doaj +1 more source
A note on directed adjusted profile likelihoods [PDF]
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
SARTORI, NICOLA +2 more
openaire +4 more sources
Are profile likelihoods likelihoods? No, but sometimes they can be
We offer our two cents to the ongoing discussion on whether profile likelihoods are "true" likelihood functions, by showing that the profile likelihood function can in fact be identical to a marginal likelihood in the special case of normal models.
Huang, Alan, Kim, Andy Sangil
openaire +2 more sources
Challenges of profile likelihood evaluation in multi-dimensional SUSY scans [PDF]
Statistical inference of the fundamental parameters of supersymmetric theories is a challenging and active endeavor. Several sophisticated algorithms have been employed to this end. While Markov-Chain Monte Carlo (MCMC) and nested sampling techniques are
Trotta, R +14 more
core +1 more source
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
For life-long learning, an effective learning strategy repertoire is particularly important during acquisition of knowledge in lower secondary school—an educational level characterized with transition into more autonomous learning environments with ...
Diana Kwarikunda +3 more
doaj +1 more source
We investigate the asymptotic distribution of the profile likelihood ratio (PLR) when constraining effective field theories (EFTs) and show that Wilks' theorem is often violated, meaning that we should not assume the PLR to follow a $\chi^2$-distribution.
Florian Urs Bernlochner, Daniel C. Fry, Stephen Burns Menary, Eric Persson
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
We reanalyze the spectral lag data for 56 Gamma-Ray Bursts (GRBs) in the cosmological rest frame to search for Lorentz Invariance Violation (LIV) using frequentist inference.
Vyaas Ramakrishnan, Shantanu Desai
doaj +1 more source

