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Profile likelihood for estimation and confidence intervals [PDF]

, 2017
Normal-based confidence intervals for a parameter of interest are inaccurate when the sampling distribution of the estimate is nonnormal. The technique known as profile likelihood can produce confidence intervals with better coverage. It may be used when
Royston, Patrick
core   +1 more source

Self-concordant profile empirical likelihood ratio tests for the population correlation coefficient: A simulation study [PDF]

, 2014
We present results of a simulation study regarding the finite-sample type I error behavior of the self-concordant profile empirical likelihood ratio (ELR) test for the population correlation coefficient.
Thorsten Dickhaus, Dickhaus, Thorsten
core   +1 more source

Goal Attainment: A Clinically Meaningful Measure of Success of Botulinum Toxin-A Treatment for Lower Limb Spasticity in Ambulatory Patients

Archives of Rehabilitation Research and Clinical Translation, 2021
Objectives: The objectives of this study were to evaluate whether botulinum toxin type A (BoNT-A) treatment for lower limb spasticity leads to patient goal attainment and identify factors associated with positive goal attainment and to assess the effect ...
Subbuh Choudhry, MBBS, Benjamin L. Patritti, PhD, Richard Woodman, PhD, Paul Hakendorf, MPH, Lydia Huang, MBBS   +4 more
doaj   +1 more source

Internalizing Symptom Profiles Among Youth in Foster Care: A Comparison Study

Frontiers in Psychiatry, 2021
Background: A high prevalence of anxiety and depression is found among youth in foster care. There is limited knowledge on the anxiety and depression symptom profiles of youth in foster care. We examined latent profiles of anxiety and depression symptoms
Yasmin Moussavi, Yasmin Moussavi, Kyrre Breivik, Gro Janne Wergeland, Gro Janne Wergeland, Bente Storm Mowatt Haugland, Marit Larsen, Marit Larsen, Stine Lehmann, Stine Lehmann   +9 more
doaj   +1 more source

Using PyBioNetFit to leverage qualitative and quantitative data in biological model parameterization and uncertainty quantification

Frontiers in Immunology
Data generated in studies of cellular regulatory systems are often qualitative. For example, measurements of signaling readouts in the presence and absence of mutations may reveal a rank ordering of responses across conditions but not the precise extents
Ely F. Miller, Abhishek Mallela, Abhishek Mallela, Jacob Neumann, Yen Ting Lin, Yen Ting Lin, William S. Hlavacek, William S. Hlavacek, Richard G. Posner   +8 more
doaj   +1 more source

Profile Likelihood

Freakonometrics, 2015
Consider some simulated data set.seed(1) x=exp(rnorm(100)) Assume that those data are observed i.id. random variables with distribution, with . The natural idea is to consider the maximum likelihood estimator For instance, consider some maximum ...
Arthur Charpentier
openaire   +2 more sources

Structured methods for parameter inference and uncertainty quantification for mechanistic models in the life sciences

Royal Society Open Science
Parameter inference and uncertainty quantification are important steps when relating mathematical models to real-world observations and when estimating uncertainty in model predictions.
Michael J. Plank, Matthew J. Simpson
doaj   +1 more source

Maximum-likelihood model averaging to profile clustering of site types across discrete linear sequences. [PDF]

PLoS Computational Biology, 2009
A major analytical challenge in computational biology is the detection and description of clusters of specified site types, such as polymorphic or substituted sites within DNA or protein sequences.
Zhang Zhang, Jeffrey P Townsend
doaj   +1 more source

Profiles on Adolescent Internet Addiction: A Taxonomy with Latent Profiling Analysis

Acta Médica Portuguesa, 2022
Introduction: Addictive use of the Internet among adolescents has been linked to a negative psychosocial development, but more detailed information about Internet addiction (IA) profiles is warranted. The aim of this study was to identify IA profiles in
Miguel Vieira Martins, Ricardo Gouveia Rodrigues, Paula Saraiva Carvalho, Sofia Ferreira   +3 more
doaj   +1 more source

Identifying Risk Profiles of Malignant Prostate Cancer Surgical Delay Using a Person-Centered Approach to Understand Prostate Cancer Disparities: The Constellation of Health Determinants Using Latent Class Analysis on Cancer Registry Data

American Journal of Men's Health, 2020
Surgical prostate cancer (PCa) treatment delay (TD) may increase the likelihood of recurrence of disease, and influence quality of life as well as survival disparities between Black and White men.
Francisco A. Montiel Ishino PhD, MPH, Claire Rowan BS, Rina Das PhD, Janani Thapa PhD, Ewan Cobran PhD, Martin Whiteside PhD MSPH, Faustine Williams PhD, MPH MS   +6 more
doaj   +1 more source