Results 131 to 140 of about 3,277,020 (308)
Leadership in Jihadist Terrorist Organizations
Free University Journal of Asian Studies, 2020 On May 2, 2011, Al-Qaeda leader Usama Bin Laden was assassinated in Abbottabad, Pakistan. This special operation was planned and carried out within the framework of the US counterterrorism strategy. It was recognized as a US victory over terrorism. After
Tinatin Karosanidze
doaj
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Higher education students’ sociocultural profiles and career resources: The role of grit
Educación XX1This study was grounded on a theoretical framework that integrates Bourdieu's concept of sociocultural capital with Blustein's Relational Theory of Working, which recognizes that social structures and interpersonal connections shape career trajectories.
Sílvia Monteiro +4 more
doaj +1 more source
profileR: An R package for profile analysis [PDF]
Journal of Open Source Software, 2020 Christopher Desjardins, Okan Bulut
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Profiles (Winter, 2008) v.7 (1)
, 2008 Contents ␣␣ VDL Tools Up For Fish Testing . . . . 3 ␣␣ CVM Provides Leadership in International Avian Influenza Surveillance 5 ␣␣ College Granted Full Accreditation 6 ␣␣ College Announces Affiliation With Davis Family Dairies 7 ␣␣ Research ...
Ames, Trevor: Interim Dean +7 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source