Results 111 to 120 of about 3,821,770 (397)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A General Theory of Sample Complexity for Multi-Item Profit Maximization

open access: yes, 2018
The design of profit-maximizing multi-item mechanisms is a notoriously challenging problem with tremendous real-world impact. The mechanism designer's goal is to field a mechanism with high expected profit on the distribution over buyers' values ...
Balcan, Maria-Florina   +2 more
core  

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

DYNAMICS OF THE INCIDENCE OF NON-COMMUNICABLE DISEASES OF THE GENITOURINARY SYSTEM AMONG THE POPULATION OF UKRAINE

open access: yesActa Medica Leopoliensia
Aim. Accessibility, timeliness, and patient-centered approach are among the main elements in ensuring the quality of medical care; therefore, the aim of the study was to analyze and process epidemiological data on certain nosological entities of ...
Taras Gutor   +3 more
doaj   +1 more source

Not-for-profit organizations work well in caring services. But expectations of their playing an increased role in Big Society changes may not be well-founded [PDF]

open access: yes, 2011
The beleaguered Big Society concept argues that not-for-profit organizations can and should deliver a much larger proportion of the ‘caring’ services in education, social care and the health sectors.
Smith, Sarah
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Comparative Analyses of Green Plantlet Regeneration in Barley (Hordeum vulgare L.) Anther Culture

open access: yesAgriculture
The efficient doubled haploid (DH) plant production methods play a key role in accelerating the breeding of new varieties and hybrids in cultivated plants. Consequently, DH plant production methods are continuously improving for barley (Hordeum vulgare L.
Csaba Lantos   +3 more
doaj   +1 more source

Equilibrium unemployment under negotiated profit sharing [PDF]

open access: yes
We study employment, employee effort, wages and profit sharing when firms face stochastic revenue shocks and when base wages and profit shares are determined through collective bargaining.
Koskela, Erkki, Stenbacka , Rune
core  

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