Results 91 to 100 of about 3,228,375 (306)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Many countries suffer from persistently high unemployment rates. The scope for labour market reforms is often limited to measures that hurt neither shareholders nor workers.
Ronnie Schöb
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Assessment of the thrust force of UAV slotted propellers
Авіаційно-космічна техніка та технологіяThe thrust characteristics of slotted propellers of an unmanned aerial vehicle are the subject of the study. The study object is a slotted propeller of an unmanned aerial vehicle.
Liubov Markovska +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
MIRCIM 2025: Ten Years of Scientific Dialogue in Evidence-Based Medicine
Львівський клінічний вісникThe 10th McMaster International Review Course in Internal Medicine (MIRCIM 2025), held in Kraków, Poland, confirmed its status as a high-impact scientific forum promoting evidence-based medical practice. With over 100 speakers from more than 40 countries,
T. Nehrych +6 more
doaj +1 more source
A General Theory of Sample Complexity for Multi-Item Profit Maximization
, 2018 The design of profit-maximizing multi-item mechanisms is a notoriously challenging problem with tremendous real-world impact. The mechanism designer's goal is to field a mechanism with high expected profit on the distribution over buyers' values ...
Balcan, Maria-Florina +2 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Flexible Outsourcing, Profit Sharing and Equilibrium Unemployment [PDF]
We analyze the questions associated with flexible outsourcing both with committed and flexible profit sharing under imperfect domestic labour markets. How does profit sharing influence flexible outsourcing?
Erkki Koskela, Jan König
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