Results 111 to 120 of about 3,228,375 (306)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
L’éducation dans les dix pays entrant dans l’Union européenne
Revue Internationale d’Éducation de Sèvres, 2004 Françoise Profit
doaj +1 more source
ULTRASOUND QUALITY INDICATORS AS MEASURES OF COMPETITIVENESS FOR A PRIVATE HEALTHCARE FACILITY
Acta Medica LeopoliensiaAim. Investigation and identification of ultrasound diagnostic quality indicators for the management of private diagnostic facilities, departments, or ultrasound units. Materials and Methods. Applied methods: systemic approach, bibliographic analysis,
Yuliya Nastyukha +4 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Les ressources internationales en éducation
Revue Internationale d’Éducation de Sèvres, 2004 Françoise Profit
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
‘Mind the professional gap’: exploring how doctors experience working in peripheral areas
BMC Health Services ResearchBackground The shortage of medical professionals in peripheral areas is an international challenge, not only in the developing world but also in developed countries. This jeopardises the quality and equity of care provision.
Marco Sartirana +3 more
doaj +1 more source
Profit sharing and innovation. [PDF]
profit sharing; product innovation; process innovation; non-parametric matching; conditional difference-in-differences;
Aerts, Kris, Kraft, Kornelius
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source