Results 231 to 240 of about 3,228,375 (306)

Global health is in crisis: to reach neglected patients, we need to reimagine medical research. [PDF]

BMJ Glob Health
Pizarro L.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing agricultural production for economic sustainability of sunflower across climatic zones. [PDF]

Sci Rep
Gürkan H, Bulut H, Hoogenboom G.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

For-Profit Program for All Inclusive Care for the Elderly Plans and Patient Characteristics.

JAMA Netw Open
Miller KEM, Meyers DJ.
europepmc   +1 more source

Pricing and procurement strategies in the relief supply chain via bidirectional option contract. [PDF]

PLoS One
Maleki Rastaghi M, Barzinpour F, Heydari J, Gholamian MR.   +3 more
europepmc   +1 more source

Trends in Electronic Health Record Use Among Adult Day Services Centers, 2016-2022: A Cross-Sectional Panel Study. [PDF]

Health Sci Rep
Li Y, Lendon JP, Kindilien S, Caffrey C.
europepmc   +1 more source

Delineating profit gaps in rice and wheat production: evidence from India's economically marginalized region. [PDF]

Agric Food Econ
Ajay A, Mkondiwa M, Urfels A, Müller D.
europepmc   +1 more source

Balancing efficiency and clinical quality in dialysis centers: Insights from a nationwide DEA study in Taiwan. [PDF]

PLoS One
Yeh SJ, Wang WC, Pruett A, Chou HC.
europepmc   +1 more source