Results 291 to 300 of about 3,821,770 (397)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Advancing the use of artificial intelligence in health technology assessment activities: insights and next steps from the 2025 HTAi Global Policy Forum. [PDF]

Int J Technol Assess Health Care
Trowman R, Boysen M, Migliore A, Valiotis G.   +3 more
europepmc   +1 more source

Bridging Policy and Practice in Telemedicine Follow-Up Identification: Multicenter Mixed Methods Study in Beijing.

JMIR Hum Factors
Lyu Y, Li X, Li H, Gu M, Xu X, Wang Y, Jin C.   +6 more
europepmc   +1 more source

A prospective observational study of how veterinary clinics and their clients utilized a no-credit-check, third-party managed installment financing option to increase access to veterinary care. [PDF]

Front Vet Sci
Cammisa HJ, Hill S.
europepmc   +1 more source

Equilibrium with profit rate maximizing producers [PDF]

Kirill Borisov
openalex  

Causal loop diagramming the dynamics that shape food environments in Dutch supermarkets. [PDF]

BMC Med
Middel CNH, Colizzi C, Waterlander W, Dijkstra SC, Beulens JWJ, Mackenbach JD.   +5 more
europepmc   +1 more source

Location of births by health facility type: a time trend analysis from 1995 to 2023 in 130 low- and middle-income countries. [PDF]

EClinicalMedicine
Gage A, Conrad M, Sumich C, Warriner W, Banke-Thomas A, Bintz C, Bienhoff K, Bishai J, Dandona R, Dirac MA, Glucksman T, Hay SI, Knight M, Lozano R, Mokdad AH, Mohiddin A, Ngatia B, Offosse MJ, Tukur J, Temmerman M, Stollfus B, Worku A, Barış E, Kassebaum NJ, Haakenstad A.   +24 more
europepmc   +1 more source

Mission and money: A scoping review of social enterprise business models as a solution to sustaining health-promoting food and nutrition-based initiatives. [PDF]

BMC Public Health
Fathi LI, Walker J, Dix C, Previte J, Olgacher D, Woodside J, Truby H.   +6 more
europepmc   +1 more source