Results 91 to 100 of about 70,830 (309)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Molecular genetic markers and rubber breeding in Thailand : 2 - Field stndy of the family RRIM600 x PB217 for QTL identification [PDF]

, 2006
For developing QTL detection based on the genetic linkage map of the cross RRIM600 x PB217, a clonal field trial was set in Thailand in June 2002. It will be studied until 2010 and targeted to the genetic analysis of the physiological parameters of the ...
Clément-Demange, André, Prapan, Kanlaya, Ratanawong, R., Teerawatanasuk, Kannikar   +3 more
core  

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Variação genética em progênies de Myracrodruon urundeuva F.F. & M.F. Allemão em três sistemas de cultivo Genetic variation in progenies of Myracrodruon urundeuva F.F. & M.F. Allemao in three cultivation systems

Revista Árvore, 2006
Myracrodruon urundeuva (aroeira) é uma das espécies arbóreas que apresentam madeira de maior durabilidade em contato com o solo. Em razão dessa característica, populações naturais de M. urundeuva, distribuídas por quase todo o Brasil, vêm sendo dizimadas.
Miguel Luiz Menezes Freitas, Ana Paula de Andrade Aukar, Alexandre Magno Sebbenn, Mario Luiz Teixeira de Moraes, Eliana Gertrudes Macedo Lemos   +4 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

ALTAS HERDABILIDADES E GANHOS NA SELEÇÃO PARA CARACTERES DE CRESCIMENTO EM TESTE DE PROGÊNIES DE POLINIZAÇÃO ABERTA DE Pinus elliottii Engelm var. elliottii, AOS 25 ANOS DE IDADE EM ASSIS−SP

Revista do Instituto Florestal, 2008
O objetivo deste trabalho foi estimar parâmetros genéticos para caracteres de crescimento em teste de progênies de polinização aberta de Pinus elliottii Engelm var. elliottii, aos 25 anos de idade em Assis−SP.
Alexandre Magno Sebbenn, Osmar Vilas Bôas, José Carlos Molina Max   +2 more
doaj   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Parentesco na seleção para produtividade e teores de óleo e proteína em soja via modelos mistos

Pesquisa Agropecuária Brasileira, 2013
O objetivo deste trabalho foi avaliar influência da informação de parentesco na seleção de progênies de soja quanto à produtividade e aos teores de óleo e proteína, com base no uso de modelos mistos de predição dos valores genéticos. Novecentas progênies
Larissa Correia de Melo Pinheiro, Pedro Ivo Vieira Good God, Vinícius Ribeiro Faria, Ane Gabrielle Oliveira, Aline Akemi Hasui, Eduardo Henrique Guimarães Pinto, Klever Márcio Antunes Arruda, Newton Deniz Piovesan, Maurilio Alves Moreira   +8 more
doaj   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source