Results 171 to 180 of about 70,830 (309)

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Rapid recovery of homozygous <i>Pr</i> gene introgression lines in Indian tropical cauliflower backgrounds through combined use of morphological and molecular markers. [PDF]

Front Plant Sci
Singh S, Kumar S, Verma V.
europepmc   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Gap junction-mediated signaling coordinates Rhodopsin coupling for Drosophila color vision. [PDF]

Biol Open
Zhang X, Shinjo R, Kitamata M, Otsune S, Nakagoshi H.   +4 more
europepmc   +1 more source

Analysis of the variation within Sitka spruce, lodgepole pine and loblolly pine [PDF]

, 1981
Cahalan, C.M., Cannell, M.G.R.
core  

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Integrated Analysis of Genetic, Spectral, Phenotypic, and Stress-Resistant Traits in <i>Vanda</i> × <i>Papilionanthe</i> Intergeneric Hybrids. [PDF]

Plants (Basel)
Li H, Cui XQ, Zhang ZB, Li JW.
europepmc   +1 more source

Strategies to develop oil palm clones for Latin American and Africa [PDF]

, 2010
Amblard, Philippe, Cochard, Benoît, De Franqueville, Hubert, Durand-Gasselin, Tristan, Labeyrie, Axel, Nouy, Bruno, Potier, Françoise   +6 more
core  

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Rice sucrose transporter 1, <i>OsSUT1</i>, confers to alleviation of the high temperature stress in rice grain filling. [PDF]

Plant Biotechnol (Tokyo)
Kusano H, She KC, Matsubara K, Wang LL, Tsujiuchi K, Matsumoto R, Shiraishi M, Okubo Y, Yasui H, Sasaki T, Shimada H.   +10 more
europepmc   +1 more source