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Progesterone and pregnancy

Current Opinion in Obstetrics & Gynecology, 2005
Progesterone is an essential hormone in the process of reproduction. Although the pharmacokinetics and pharmacodynamics of progesterone have been well studied, its use in the pathophysiology of pregnancy remains controversial. One of these concerns is the way in which the hormone is administered.In obstetrics the most frequent uses of progesterone are ...
Miroslava Gojnic   +3 more
openaire   +3 more sources

Progesterone

2016
Progesterone (P4) is an an intermediate of sex steroids produced by all steroidogenic tissues. It maintains pregnancy and the secretory condition of the uterine endometrium during the luteal phase, and inhibits release of gonadotropins. P4 can bind to progesterone receptor (PR), which is a member of the nuclear receptor superfamily of transcription ...
Shinichi Miyagawa   +2 more
openaire   +2 more sources

Progesterone and ovulation

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
The role of progesterone (P) in the mechanism of ovulation is controversial at best. The contraceptive application of P was established in rodents in 1936 and with orally absorbed progestogenes was put to human use. There were hints on the proovulatory actions of P administered before the time of ovulation in rats by 1948.
openaire   +3 more sources

Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor

Journal of the Society for Gynecologic Investigation, 2000
The progesterone receptor (PR), as a member of the nuclear receptor superfamily of ligand-dependent transcription factors, activates gene transcription through binding to specific palindromic progesterone response elements (PRE) in the promoter region of progestin-responsive genes.
Susan A. Leonhardt   +2 more
openaire   +3 more sources

Progesterone receptor and the mechanism of action of progesterone antagonists

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type II compounds (RU486, ZK112993, ZK98734) promote PR binding to DNA.
Angelo M. DeMarzo   +5 more
openaire   +3 more sources

Progesterone increases nitric oxide synthesis in human vascular endothelial cells through activation of membrane progesterone receptor-α.

American Journal of Physiology. Endocrinology and Metabolism, 2015
Progesterone exerts beneficial effects on the human cardiovascular system by inducing rapid increases in nitric oxide (NO) production in vascular endothelial cells, but the receptors mediating these nongenomic progesterone actions remain unclear.
Y. Pang, Jing Dong, P. Thomas
semanticscholar   +1 more source

The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy.

Endocrinology, 1975
The hormonal factors associated with converting a corpus luteum of estrous cycle into a corpus luteum of pseudopregnancy were studied by measuring LH and FSH prolactin, estradiol and progesterone levels in decapitated rats during the 4-day estrous cycle ...
M. Smith, M. Freeman, J. D. Neill
semanticscholar   +1 more source

Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat.

Endocrinology, 1974
Groups of female rats were decapitated at 3-hr intervals throughout 4-day estrous cycles and the plasma of each rat was assayed for LH, FSH, prolactin, progesterone and estradiol-17β.
R. Butcher, W. E. Collins, N. W. Fugo
semanticscholar   +1 more source

The Case for Progesterone

Annals of the New York Academy of Sciences, 2005
Abstract: Recent clinical trials in hormone therapy (HT) for women approaching or past menopause have been disappointing. Most women who have been taking conjugated equine estrogens combined with synthetic progestins have been encouraged to stop these supplements because of increased health risks.
openaire   +3 more sources

PROGESTERONE IN BLOOD

Journal of Endocrinology, 1958
SUMMARY The content of progesterone was determined in the peripheral venous blood of cows from the 32nd day of pregnancy until the day before calving. The level ranged from 0·74 to 0·98 μg progesterone/100 ml. plasma throughout the 32nd-256th day period, but thereafter a marked decrease was observed, and on the day before calving the level ...
openaire   +6 more sources

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