Proliferative Effects of Estradiol, Progesterone, and Two CB Congeners and Their Metabolites on Gray Seal (Halichoerus grypus) Uterine Myocytes in Vitro [PDF]
Toxicological Sciences, 2003 Gray seal females living in the Baltic Sea have been found to exhibit a high prevalence of uterine leiomyomas. These animals are also known to accumulate lipid-soluble PCBs in their blubber. PCBs have documented endocrine-disrupting effects; to investigate whether the PCBs could be part of the genesis of uterine smooth muscle tumors in this species ...
Matts Olovsson +2 more
openaire +4 more sources
Endocrine Regulations, 2010 Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in a wide variety of products. They show an accumulation pattern similar to that of well-known persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), DDT and others. So far, most of information showing adverse effects of various POPs was based on the exposure to
Karpeta A, Gregoraszczuk El
openaire +4 more sources
Case–control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women [PDF]
International Journal of Circumpolar Health, 2014 Background: Exposure to environmental chemicals may impair endocrine system function. Alaska Native (AN) women may be at higher risk of exposure to these endocrine disrupting chemicals, which may contribute to breast cancer in this population. Objective:
Adrianne K. Holmes +8 more
doaj +1 more source
Multi-Constraint Molecular Generation using Sparsely Labelled Training Data for Localized High-Concentration Electrolyte Diluent Screening [PDF]
Digital Discovery (2023), 2023 Recently, machine learning methods have been used to propose molecules with desired properties, which is especially useful for exploring large chemical spaces efficiently. However, these methods rely on fully labelled training data, and are not practical in situations where molecules with multiple property constraints are required.
arxiv +1 more source
Ecotoxicology and Environmental Safety, 2022 Air pollution includes polycyclic aromatic hydrocarbons (PAHs), which have been correlated to endocrine disruptor pathways during early pregnancy. PAHs have been found in the placenta and cord blood, which may affect the hormones involved in placental ...
Jhon Fredy Narváez Valderrama +10 more
doaj
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec [PDF]
arXiv, 2021 We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provides insights into the evolution of steroid activation of human PR.
arxiv
Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption [PDF]
arXiv, 2021 There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisphenol A, and pesticides, such as DDT. These endocrine-disrupting chemicals influence steroid-mediated physiology in humans and other vertebrates by competing with steroids ...
arxiv
Multi-Kink Quantile Regression for Longitudinal Data with Application to the Progesterone Data Analysis [PDF]
arXiv, 2021 Motivated by investigating the relationship between progesterone and the days in a menstrual cycle in a longitudinal study, we propose a multi-kink quantile regression model for longitudinal data analysis. It relaxes the linearity condition and assumes different regression forms in different regions of the domain of the threshold covariate.
arxiv
Where to place the positive muon in the Periodic Table? [PDF]
Physical Chemistry Chemical Physics 17 (2015) 7023, 2014 In a recent study it was suggested that the positively charged muon is capable of forming its own "atoms in molecule"s (AIM) in the muonic hydrogen-like molecules, composed of two electrons, a muon and one of the hydrogen isotopes, thus deserved to be placed in the Periodic Table [Phys. Chem. Chem. Phys. 16, 6602, 2014]. In present report, the capacity
arxiv +1 more source
Are microbial biosurfactants actually only surfactants? [PDF]
, 2023 The term biosurfactants refers to a complex mixture of metabolites with surface-active properties produced by specific microorganisms. However, nowadays trends moves towards isolation, screening and purifying single biocompatible, biodegradable biosurfactants with high commercialization potential.
arxiv +1 more source