Results 11 to 20 of about 2,401 (213)

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects [PDF]

, 2016
Humans are exposed to a large number of environmental chemicals in their daily life, many of which are readily detectable in blood or urine. It remains uncertain if these chemicals can cause adverse health effects when present together at low doses.
Egebjerg, Karen Mandrup, Frandsen, Henrik Lauritz, Frederiksen, Hanne, Hadrup, Niels, Pedersen, Mikael, Skov, Kasper, Svingen, Terje, Vinggaard, Anne Marie   +7 more
core   +2 more sources

Levels and enantiomeric signatures of methyl sulfonyl PCB and DDE metabolites in livers of harbor porpoises (Phocoena phocoena) from the southern North Sea [PDF]

, 2003
The concentration of 26 methyl sulfonyl metabolites of polychlorinated biphenyls (MeSO2-PCBs) and of p,p'-DDE (MeSO2-DDE) were determined in 19 liver samples from harbor porpoises (Phocoena phocoena) stranded between 1997 and 2000 on the Belgian and ...
Berggren P., Bergman, Boon J. P., Boon J. P., Boon J. P., Brandt I., Chu S. G., Chu S. G., Chu S. G., Covaci A., Ellerichmann T., Haraguchi K., Haraguchi K., Harner T., Hühnerfuss H., Hühnerfuss H., Jensen S., Kaiser K. L. E., Karlson K., Koake G., Larsen G. L., Larsson C., Letcher R. J., Letcher R. J., Letcher R. J., Nagayama J., Nezel T., Tanabe S., Troisi G. M., Troisi G. M., Weistrand C., Wiberg K.   +31 more
core   +1 more source

Human endometrial cell coculture reduces the endocrine disruptor toxicity on mouse embryo development [PDF]

, 2012
BACKGROUNDS: Previous studies suggested that endocrine disruptors (ED) are toxic on preimplantation embryos and inhibit development of embryos in vitro culture.
Hae-Hyeog Lee, Ho-Yeon Song, Myeong-Seop Lee, Young-Sang Lee   +3 more
core   +1 more source

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System. [PDF]

, 2010
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Abel, Alger, Alpha Gebeh, Anthony H. Taylor, Aquila, Aquila, Aquila, Arnone, Barrett, Battista, Battista, Bisogno, Blankman, Bray, Bray, Carreau, Chabbert Buffet, Chmurzynska, Cobellis, Devane, Devane, Di Marzo, Di Marzo, Di Marzo, Dinh, El-Talatini, El-Talatini, Evers, Fonseca, Francavilla, Furuhashi, Geber, Gervasi, Godlewski, Gong, Grimaldi, Guo, Guzeloglu-Kayisli, Habayeb, Habayeb, Habayeb, Habayeb, Helliwell, Horne, Idris, Jonathon M. Willets, Justin C. Konje, Kaczocha, Katerina N. Bambang, Kim, Lambert, Larqué, Leung, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maingret, Matsuda, Mechoulam, Mechoulam, Meizel, Muccioli, Munro, Newton, Nixon, O'Sullivan, Okamoto, Pan, Pandey, Paria, Paria, Paria, Paria, Paria, Park, Patricia Lam, Pestonjamasp, Piccini, Pierantoni, Ravinet Trillou, Regan, Rodriguez de Fonseca, Rodriguez de Fonseca, Ross, Rossato, Rossi, Schmid, Schuel, Schuel, Schuel, Schuel, Simiand, Sipe, Smith, Sofikitis, Sriraman, Sun, Tapia, Taylor, Taylor, Timothy H. Marczylo, Toth, Trabucco, Tsuboi, Tulay Karasu, Turco, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wenger, Wenger, Yamano, Yang   +125 more
core   +2 more sources

Synthesis and biological evaluation of novel amidinourea and triazine congeners as inhibitors of MDA-MB-231 human breast cancer cell proliferation [PDF]

, 2017
A series of novel amidinourea derivatives has been synthesised and the new compounds have been evaluated as inhibitors of MDA-MB-231 human breast cancer cell proliferation.
Bass, Rosemary, Castagnolo, Daniele, Jenkinson, Sarah, Marshall, Jamie, Smulders-Srinivasan, Tora, Wright, Jennifer   +5 more
core   +4 more sources

Background fish feminization effects in European remote sites [PDF]

, 2015
Human activity has spread trace amounts of chemically stable endocrine-disrupting pollutants throughout the biosphere. These compounds have generated a background level of estrogenic activity that needs to be assessed.
Catalan, Jordi, Gallego Piñol, Eva, Jarque, Sergio, Lackner, Reinhard, Obrador Grimalt, Joan, Piña, Benjamí, Quirós, Laia   +6 more
core   +3 more sources

Bioaccumulation of PCB & DDE methyl sulfones in marine mammals and their interactions with receptor proteins [PDF]

, 2000
PCB and DDE-Methyl sulphone metabolites are the product of enzymatic and bile acid entero hepatic metabolism in the final phase (III) of PCB and DDE detoxification in mammals following hepatic microsomal cytochrome P450-dependent metabolism (phase I) and
Aguilar, A, Borrell, A, Haraguchi, K, Mattson, M, Siebert, U, Troisi, GM   +5 more
core  

Early developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex. [PDF]

, 2011
peer reviewedSex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to ...
Bourguignon, Jean-Pierre, GERARD, Arlette, Naveau, Elise, Parent, Anne-Simone, Westbrook, Gary L   +4 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may influence birth weight among infants in a Swedish cohort with background exposure: a cross-sectional study [PDF]

, 2013
BACKGROUND: Prenatal exposure to persistent organic pollutants, e.g. polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) has been suggested to negatively affect birth weight although epidemiological evidence is still inconclusive.
Anders Glynn, Annika Hanberg, Marie Aune, Per Ola Darnerud, Sanna Lignell, Susanna C Larsson   +5 more
core   +1 more source