Results 41 to 50 of about 2,330 (251)

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

Uso de la anticoncepción con solo gestágenos en atención primaria: estudio GESTAGAP

Atención Primaria, 2019
Resumen: Objetivo: Estimar la prevalencia de uso de anticoncepción hormonal de solo gestágenos (AHSG) entre las mujeres demandantes de anticoncepción reversible en atención primaria (AP).
Raquel Rodríguez-Rodríguez, Elena Polentinos-Castro, Amaya Azcoaga-Lorenzo, Cristina González-Fernández, Raquel Rodríguez Rodríguez, Vera González García, Isabel Zamarrón Méndez, Alicia Alonso López, Aranzazu Vigil-Escalera Villaamil, Diana Campodonico, Pilar Kloppe Villegas, Rafael Beijinho do Rosario, Juan Antonio López-Rodríguez, Martín Sebastian Pessagc, Sergio Pescador Saster, Rocío García-Gutiérrez Gómez, Belén Arellano Borreguero, Rafael Gómez Moreno, Cristina González Fernández, Cristina Muñoz Martínez de Salinas, Carmen Sanz Rodrigo, Carmen M. Muros Muñoz, M. José Iglesias Piñeiro, Pilar Sanz Velasco, M. Rosario Aylon Carrasco, Rafael López Navarro, Santiago Prada Mansilla, Beatriz Fernández Virgala, Concepción Bravo Pache, Carmen Vaillo Muñoz, Dolores Peñalva Merino, Elena Barrios Rueda, Francisca Melian Nuez, Rocío Triano Sánchez, Miguel Ángel Martínez Álvarez, Ana I. Moreno Gómez, Margarita Puerto Rodríguez, Gustavo Mora Navarro, M. Dolores Martín Álvarez, Sara Ascensión Pérez Medina, Raquel Cabral Rodríguez, Mónica Yanes Baonza, Emilia Arrébola Vivas, Alberto González Hernández, Celia Sala Arnaiz, Elena A. González Romero, Marta Chamorro Gavela, Alejandra Rodríguez Martín, Amaya Azcoaga Lorenzo, Elena Polentinos Castro   +49 more
doaj  

Multigenerational and Transgenerational Effects of Dioxins [PDF]

, 2019
Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still reason for concern. There is mounting evidence from both epidemiological and experimental studies that paternal exposure to the most potent congener of ...
Pohjanvirta, Raimo, Viluksela, Matti
core   +3 more sources

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

IYPt is a highly polar, nonlinear triatomic molecule [PDF]

, 2019
An explorative quantum chemical study of the triatomic molecule IYPt, its isomers, group 17 congeners, and dimer is carried out. The results indicate that IYPt is a ground-state singlet with a bent geometry and a large electric dipole moment of magnitude 4.8 D.
arxiv   +1 more source

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]

, 2016
We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M., Cotinot, C., Evans, N.P., Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Rhind, S., Sharpe, R.M.   +7 more
core   +2 more sources

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Possible Effects of Persistent Organic Pollutants on Steroid Hormone Homeostasis in House Sparrows (Passer domesticus) from Helgeland, Norway [PDF]

, 2014
Over the last decades, declines have occurred in the range and abundance of several passerines and farmland bird species and even though several possible causes have been suggested, the exposure to environmental contaminants and intensification of ...
Nossen, Ida
core  

Indirect assessment of hemorrhoid incidence using invasive treatment data in Japan: A 5‐year study based on nationwide health insurance claims

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to clarify the epidemiology of hemorrhoids by leveraging a comprehensive nationwide healthcare claims database in Japan. By analyzing invasive treatments for hemorrhoids over a 5‐year period (2018–2022), we identified key demographic patterns, including distinct bimodal peaks in incidence among males and females, and highlighted ...
Masamitsu Kido, Tomohiro Arita, Katsutoshi Shoda, Ken Inoue, Hiroyuki Okimura, Hiroki Shimizu, Jun Kiuchi, Kenji Nanishi, Atsushi Shiozaki   +8 more
wiley   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2011
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Nicolaou, A, Mauro, C, Urquhart, P, Marelli-Berg, F   +3 more
core   +5 more sources