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Clinical pharmacology of progestins
Minerva Obstetrics and Gynecology, 2022In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use.We review scientific literature on the topic ...
Capozzi, Anna +2 more
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, 1995
Objective. —To assess pairwise differences between placebo, unopposed estrogen, and each of three estrogen/progestin regimens on selected heart disease risk factors in healthy postmenopausal women. Design. —A 3-year, multicenter, randomized, double-blind,
V. Miller +94 more
semanticscholar +1 more source
Objective. —To assess pairwise differences between placebo, unopposed estrogen, and each of three estrogen/progestin regimens on selected heart disease risk factors in healthy postmenopausal women. Design. —A 3-year, multicenter, randomized, double-blind,
V. Miller +94 more
semanticscholar +1 more source
The relationship between progestin hormonal contraception and depression: a systematic review.
Contraception, 2018OBJECTIVE We performed a systematic review to look for an association between progestin-only contraception and depression. METHODS We searched PubMed, Ovid and Web of Science for English-language articles including progestin-only contraception and ...
Brett L. Worly, T. Gur, J. Schaffir
semanticscholar +1 more source
Maturitas, 1996
The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
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The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
openaire +2 more sources
Drospirenone: a novel progestin
Expert Opinion on Pharmacotherapy, 2007Drospirenone is a novel progestin available in combined oral contraceptives and menopausal hormonal therapy. Similar to its parent compound spirolactone, an analog of spironolactone, drospirenone has antimineralocorticoid and antiandrogenic activity.
Sharon A Winer, Andrea J. Rapkin
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Contraception, 2001
There is considerable confusion concerning the use of the term "progestin" in referring to progestational compounds. Such term is often restricted to progestational agents that are synthetic and excludes progesterone which is a natural compound. In 1930 when progesterone had not yet been isolated the term "progestin" was proposed for the name of this
Frank Z. Stanczyk, Milan R. Henzl
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There is considerable confusion concerning the use of the term "progestin" in referring to progestational compounds. Such term is often restricted to progestational agents that are synthetic and excludes progesterone which is a natural compound. In 1930 when progesterone had not yet been isolated the term "progestin" was proposed for the name of this
Frank Z. Stanczyk, Milan R. Henzl
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The androgenicity of progestins
The American Journal of Medicine, 1995All steroid hormones are structurally similar, but relatively minor differences cause profound alterations in biochemical activity. The 21-carbon series (pregnane nucleus) includes the corticoids and the true progestins (e.g., medroxyprogesterone acetate).
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On the mechanism of action of progestins
Acta Endocrinologica, 1981Abstract. The effect of two synthetic injectable progestins, norethisterone oenanthate3 (NET-e) and medroxyprogesterone acetate (MPA) upon the hypothalamic pituitary unit was evaluated in post-menopausal women (PMW) and in castrated individuals with androgen un-responsiveness in order to gain insight into their mechanism of gonadotrophin inhibition ...
Martha Medina +4 more
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The Journal of Steroid Biochemistry and Molecular Biology, 1999
While the benefits of progestin use in hormone replacement therapy (HRT) are well recognised as far as endometrial protection is concerned, their risks and drawbacks have generated controversial articles. The data related to the progestin effect on breast tissue has been interpreted differently from country to country. However it has been admitted that,
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While the benefits of progestin use in hormone replacement therapy (HRT) are well recognised as far as endometrial protection is concerned, their risks and drawbacks have generated controversial articles. The data related to the progestin effect on breast tissue has been interpreted differently from country to country. However it has been admitted that,
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Role of progestins in contraception
Acta Obstetricia et Gynecologica Scandinavica, 2005Progestins have been used for contraception for more than 30 years. The main goal was to develop a contraceptive method devoid of the metabolic or clinical side‐effects associated with the use of estrogens. The development of new contraceptive methods and formulations is time‐consuming and requires devotion, belief, and also strong economical basis. As
Risto Erkkola, Britt-Marie Landgren
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