Results 1 to 10 of about 11,052 (225)

Contraceptive Progestins With Androgenic Properties Stimulate Breast Epithelial Cell Proliferation

EMBO Molecular Medicine, 2021
Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate ...
Fabio De Martino, Valentina Scabia, Wassim Raffoul   +2 more
exaly   +2 more sources

Progestins - a review of clinical application in gynecology [PDF]

Annals of Medicine
Aims Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone (TE) or progesterone (P4) origin.
Dominika Żyła, Dominika Kuźmiuk, Martyna Rynkowska, Małgorzata Satora, Krzysztof Kułak, Rafał Tarkowski   +5 more
doaj   +2 more sources

Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk

Foods, 2023
The residues of progestins in milk are significant risk factors for teenage acne and may cause hormone-dependent cancers in consumers, so the determination of these residues in milk is very important.
Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang   +4 more
doaj   +1 more source

Fourth-Generation Progestins Inhibit 3β-Hydroxysteroid Dehydrogenase Type 2 and Modulate the Biosynthesis of Endogenous Steroids. [PDF]

PLoS ONE, 2016
Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations.
Renate Louw-du Toit, Meghan S Perkins, Jacky L Snoep, Karl-Heinz Storbeck, Donita Africander   +4 more
doaj   +1 more source

Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha

Frontiers in Endocrinology, 2022
Progestins, synthetic compounds designed to mimic the activity of natural progesterone (P4), are used globally in menopausal hormone therapy. Although the older progestins medroxyprogesterone acetate (MPA) and norethisterone (NET) have been implicated in
Meghan S. Perkins, Renate Louw-du Toit, Hayley Jackson, Mishkah Simons, Donita Africander   +4 more
doaj   +1 more source

Progestins as Anticancer Drugs and Chemosensitizers, New Targets and Applications

Pharmaceutics, 2021
Progesterone and its synthetic analogues, progestins, participate in the regulation of cell differentiation, proliferation and cell cycle progression.
Tatiana A. Fedotcheva, Nadezhda I. Fedotcheva, Nikolai L. Shimanovsky   +2 more
doaj   +1 more source

Possible Participation of Adenine Nucleotide Translocase ANT1 in the Cytotoxic Action of Progestins, Glucocorticoids, and Diclofenac on Tumor Cells

Pharmaceutics, 2023
A comparative analysis of the cytostatic effects of progestins (gestobutanoyl, megestrol acetate, amol, dienogest, and medroxyprogesterone acetate), glucocorticoids (hydrocortisone, dexamethasone), and diclofenac on tumor cells was carried out in order ...
Darya Ulchenko, Lilia Miloykovich, Olga Zemlyanaya, Nikolay Shimanovsky, Tatiana Fedotcheva   +4 more
doaj   +1 more source

Effects of oral contraceptives on metabolic parameters in adult premenopausal women: a meta-analysis

Endocrine Connections, 2020
Objective: To estimate the effect of oral contraceptives (OC) containing di fferent progestins on parameters of lipid and carbohydrate metabolism through a systematic review and meta-analysis. Patients and methods: Premenopausal women aged 18 or older,
Lina S Silva-Bermudez, Freddy J K Toloza, Maria C Perez-Matos, Russell J de Souza, Laura Banfield, Andrea Vargas-Villanueva, Carlos O Mendivil   +6 more
doaj   +1 more source

Therapeutic options of endometrial hyperplasia management. Current recommendations and prospective directions of treatment

Репродуктивная эндокринология, 2021
Endometrial hyperplasia (EH) is a pathological condition characterized by proliferation of the endometrial glands with an increase in the glands/stroma ratio compared to normal proliferative endometrium. EH is a precursor to the development of one of the
T.F. Tatarchuk, T.I. Kvasha, N.F. Zakharenko, N.V. Kosei, V.S. Solskyy, I.V. Shmulian   +5 more
doaj   +1 more source

Endometrial hyperplasia and progesterone resistance: a complex relationship

RUDN Journal of Medicine, 2023
The endometrium is one of the most dynamic tissues that constantly undergoes changes during the menstrual cycle in women of the reproductive period. All these processes take place mainly under the influence of steroid hormones that are produced in the ...
Mekan R. Orazov, Ludmila M. Mikhaleva, Irina A. Mullina   +2 more
doaj   +1 more source