Results 1 to 10 of about 14,033 (271)

Progestins - a review of clinical application in gynecology [PDF]

Annals of Medicine
Aims Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone (TE) or progesterone (P4) origin.
Rafał Tarkowski, Krzysztof Kułak, Małgorzata Satora   +2 more
exaly   +4 more sources

Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation [PDF]

EMBO Molecular Medicine, 2021
Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate ...
Marie Shamseddin, Fabio De Martino, Céline Constantin, Valentina Scabia, Anne‐Sophie Lancelot, Csaba Laszlo, Ayyakkannu Ayyannan, Laura Battista, Wassim Raffoul, Marie‐Christine Gailloud‐Matthieu, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, George Sflomos, Cathrin Brisken   +14 more
doaj   +2 more sources

Progestins as Anticancer Drugs and Chemosensitizers, New Targets and Applications

Pharmaceutics, 2021
Progesterone and its synthetic analogues, progestins, participate in the regulation of cell differentiation, proliferation and cell cycle progression.
Tatiana A. Fedotcheva, Nadezhda I. Fedotcheva, Nikolai L. Shimanovsky   +2 more
doaj   +2 more sources

Estrogen-progestins and progestins for the management of endometriosis

Fertility and Sterility, 2016
Endometriosis is characterized by frequent recurrences of symptoms and lesions even after extirpative surgery. Because medical therapies control but do not cure the disease, long periods of pharmacologic management may be needed until pregnancy desire or, sometimes, physiologic menopause.
P. Vercellini, L. Buggio, N. Berlanda, G. Barbara, E. Somigliana, S. Bosari   +5 more
openaire   +4 more sources

Fourth-Generation Progestins Inhibit 3β-Hydroxysteroid Dehydrogenase Type 2 and Modulate the Biosynthesis of Endogenous Steroids. [PDF]

PLoS ONE, 2016
Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations.
Renate Louw-du Toit, Meghan S Perkins, Jacky L Snoep, Karl-Heinz Storbeck, Donita Africander   +4 more
doaj   +3 more sources

Progestins in HRT: Sufferance or desire?

Maturitas, 2009
While the benefits of progestins in hormonal replacement therapy are well recognized as far as endometrial protection is concerned the data on breast tissue and the cardiovascular system are contentious. Following the Women's Health Initiative study, the Million Women Study and The Women's International Study of Long-duration (O)estrogen after ...
Skouby, Sven O, Jespersen, Joergen
openaire   +6 more sources

Medical treatment for adenomyosis: long term use of progestins

Gynecological Endocrinology
Background Adenomyosis is a uterine disorder causing menstruation-related symptoms such as dysmenorrhea, heavy menstrual bleeding (HMB) and dyspareunia. A long-term management of the disease is required.
Silvia Vannuccini, Francesco La Torre, Federico Toscano, Anna Rosa Speciale, Milo Giani, Dilruba Tureli, Virginia Manzi, Angela Gallone, Felice Petraglia   +8 more
doaj   +2 more sources

Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk

Foods, 2023
The residues of progestins in milk are significant risk factors for teenage acne and may cause hormone-dependent cancers in consumers, so the determination of these residues in milk is very important.
Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang   +4 more
doaj   +1 more source

Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha

Frontiers in Endocrinology, 2022
Progestins, synthetic compounds designed to mimic the activity of natural progesterone (P4), are used globally in menopausal hormone therapy. Although the older progestins medroxyprogesterone acetate (MPA) and norethisterone (NET) have been implicated in
Meghan S. Perkins, Renate Louw-du Toit, Hayley Jackson, Mishkah Simons, Donita Africander   +4 more
doaj   +1 more source

Possible Participation of Adenine Nucleotide Translocase ANT1 in the Cytotoxic Action of Progestins, Glucocorticoids, and Diclofenac on Tumor Cells

Pharmaceutics, 2023
A comparative analysis of the cytostatic effects of progestins (gestobutanoyl, megestrol acetate, amol, dienogest, and medroxyprogesterone acetate), glucocorticoids (hydrocortisone, dexamethasone), and diclofenac on tumor cells was carried out in order ...
Darya Ulchenko, Lilia Miloykovich, Olga Zemlyanaya, Nikolay Shimanovsky, Tatiana Fedotcheva   +4 more
doaj   +1 more source