Results 21 to 30 of about 11,052 (225)

Progestin-only implant contraception (a review of global clinical guidelines)

Медицинский совет, 2015
The article reviews global clinical recommendations for progestin-only implant contraception. The efficacy, safety, risks and side effects of subdermal implants Implanon and Implanon NXT are described.
O. A. Pustotina
doaj   +1 more source

Positive association between progestins and the evolution of multiple fibroadenomas in 72 women

Endocrine Connections, 2020
Objective: Multiple fibroadenomas (MFA) of the breast is a rare benign dis ease, thus its natural history is poorly understood. The aim of our study was to describe the radiological evolution of MFA and to evaluate the influence of d ifferent factors on ...
Virginie Grouthier, Zeina Chakhtoura, Isabelle Tejedor, Yasmina Badachi, Vincent Goffin, Philippe Touraine   +5 more
doaj   +1 more source

Standard and Low-dose Hormone Therapy for Postmenopausal Women—Focus on the Breast

Taiwanese Journal of Obstetrics & Gynecology, 2007
Menopause occurs naturally when the ovary ceases folliculogenesis, or artificially by surgical and/or medical ablation of the ovarian function. Menopause is a hypoestrogenic state, which may adversely affect estrogen target tissues, such as the brain ...
Peng-Hui Wang, Huann-Cheng Horng, Ming-Huei Cheng, Hsiang-Tai Chao, Kuan-Chong Chao   +4 more
doaj   +1 more source

Systemic menopausal hormone therapy treatment patterns in Danish women—A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024.
Hannah K. Wood‐Kurland, Kathrine Kold Sørensen, Amalie Lykkemark Møller, Lina Steinrud Mørch, Mikkel Porsborg Andersen, Thomas Alexander Gerds, Amani Meaidi, Christian Torp‐Pedersen   +7 more
wiley   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Medical treatment for adenomyosis: long term use of progestins

Gynecological Endocrinology
Background Adenomyosis is a uterine disorder causing menstruation-related symptoms such as dysmenorrhea, heavy menstrual bleeding (HMB) and dyspareunia. A long-term management of the disease is required.
Silvia Vannuccini, Francesco La Torre, Federico Toscano, Anna Rosa Speciale, Milo Giani, Dilruba Tureli, Virginia Manzi, Angela Gallone, Felice Petraglia   +8 more
doaj   +1 more source

Metabolic alteration of circulating steroid hormones in women with gestational diabetes mellitus and the related risk factors

Frontiers in Endocrinology, 2023
BackgroundAbnormally changed steroid hormones during pregnancy are closely related to the pathological process of gestational diabetes mellitus (GDM). Our aim was to systematically profile the metabolic alteration of circulating steroid hormones in GDM ...
Na Yang, Na Yang, Wei Zhang, Cheng Ji, Jiajia Ge, Xiaoli Zhang, Meijuan Li, Min Wang, Tianqi Zhang, Jun He, Huaijun Zhu   +10 more
doaj   +1 more source

Tibolone Use Associated With Elevated Hepatocellular Carcinoma Risk: Findings From a Nationwide Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Tibolone, a synthetic steroid with estrogenic, progestogenic, and androgenic activity, is widely prescribed for menopausal symptoms, but its association with hepatocellular carcinoma (HCC) remains unclear. Using data from 117,271 women aged ≥ 45 years in the Korean National Health Insurance Service–Health Screening Cohort, we evaluated ...
Jimin Lee, Hye Jun Kim, Sun Jae Park, Sangwoo Park, Jina Chung, Jiwon Yu, Ju Hyun Kang, Seogsong Jeong, Hyun‐Young Shin, Sang Min Park   +9 more
wiley   +1 more source