Results 121 to 130 of about 507,437 (241)

How to do a systematic review [PDF]

, 2018
Alex Pollock, Banks JL, Barnett-Page E, Barnett-Page E, Bastian H, Berge E, Bobath B, Boers M, Boger EJ, Booth A, Booth A, Borah R, Brazzelli M, Cahill LS, Carr JH, Chalmers I, Chalmers I, Craig P, Davies PM, Deeks JJ, Dixon-Woods M, Eivind Berge, Fain JA, Feigin VL, Ganann R, Garner P, Glasziou P, Gotzsche PC, Gough D, Gough D, Gough D, Green BN, Greenwood N, Grimshaw J, Guyatt GH, Guyatt GH, Harden A, Higgins JPT, Hoffmann TC, Hoffmann TC, Joanna Briggs Institute, Kastner M, Katrak P, Kirkham JJ, Kreis J, Langhorne P, Lees R, Levac D, Moher D, Moher D, Moher D, Morley RF, Pendlebury ST, Peoples H, PLoS Medicine Editors, Pollock A, Pollock A, Pollock A, Pollock A, Rathbone J, Riva JJ, Rowat A, Sackett DL, Santisteban L, Saunders DH, Silagy CA, Snilstveit B, Stroke Unit Trialists Collaboration, Stroup DF, Thomas J, Tong A, Tyson SF, Tyson SF, Vickrey BG, Waddington H, Wardlaw JM, Weir MC, Whiting PF, Wildridge V, Williamson PR, Wong G, Yaffe J   +81 more
core   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, EarlyView.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

Targeting USP1 Potentiates Radiation‐Induced Type I IFN‐Dependent Antitumor Immunity by Enhancing Oligo‐Ubiquitinated SAR1A‐Mediated STING Trafficking and Activation

Advanced Science, EarlyView.
Targeting USP1 is identified as a strategy that significantly enhances type I IFN‐dependent innate immune response within the TME following radiotherapy. Mechanistically, USP1 inhibition facilitates STING trafficking from ER to Golgi by preserving K27‐linked oligo‐ubiquitination of SAR1A, thereby facilitating efficient activation of the dsDNA‐cGAS ...
Weilin Zhou, Yuxuan Zhao, Wenjing Qin, Weijian Wu, Chenyang Liao, Yiqiu Zhang, Xingli Yang, Xue Chen, Youqiao Wang, Yushan Kang, Jiaxin Wu, Jiaojiao Zhao, Junmin Quan, Xuecen Wang, Xianzhang Bu, Xin Yue   +15 more
wiley   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL‐Mediated Apoptosis

Advanced Science, EarlyView.
This study explores the application of therapeutic, focal ultrasound to noninvasively enhance the anti‐cancer effects of Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) as a targeted treatment for prostate cancer. This is achieved by mechanically activating mechanosensitive ion channels within cancer cells.
Abigail R. Fabiano, Malachy W. Newman, Jenna A. Dombroski, Schyler J. Rowland, Samantha V. Knoblauch, Jiro Kusunose, Katherine N. Gibson‐Corley, Benjamin G. Kaufman, Liqin Ren, Charles F. Caskey, Michael R. King   +10 more
wiley   +1 more source

Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Advanced Science, EarlyView.
Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function, provoking endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in multiple cancer tumor models cell lines and in vivo tumor models.
Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning   +9 more
wiley   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation

Advanced Science, EarlyView.
Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang, Yitao Cheng, Penghui Zhao, Jiageng Cai, Zhaowei Yin, Shaomin Chen, Ge Guo, Chi Zhu, Ke Liu, Lingyun Zu   +9 more
wiley   +1 more source

Lactobacillus johnsonii Generates Cyclo(pro‐trp) and Promotes Intestinal Ca2+ Absorption to Alleviate CKD–SHPT

Advanced Science, EarlyView.
The mechanism map of how L.johnsonii generates cyclo(pro‐trp) to alleviate CKD–SHPT by promoting the expression of CaSR and TRPV4 in IECs, enhancing Ca2+ absorption, and negatively feedback inhibiting iPTH secretion. Abstract Patients with chronic kidney disease (CKD) are at a high risk of developing secondary hyperparathyroidism (SHPT), which may ...
Xiong Zeng, Lihua Sun, Huichao Xie, Shenhai Gong, Caibao Lu, Zhongwei Xu, Haidi Guan, Ben Han, Wei Wang, Zhengmin Zhang, Jieying Zhou, Shuai Wang, Yihui Chen, Weidong Xiao   +13 more
wiley   +1 more source