Results 151 to 160 of about 507,437 (241)

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, EarlyView.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

Recent clinical research on the value of high-sensitivity cardiac troponin levels in prognostic evaluation after coronary artery bypass graft surgery: a narrative review. [PDF]

Cardiovasc Diagn Ther
Zhou F, Mu J.
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

A New Intrauterine Adhesions Classification System: The "Loddo Score". [PDF]

Gynecol Minim Invasive Ther
Loddo A, Kaza L, Saponara S.
europepmc   +1 more source

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source

The Role of Machine Learning Models in Predicting Cirrhosis Mortality: A Systematic Review. [PDF]

Cureus
Mohamud KA, Elzubair Eltahir SA, Ahmed Alhardalo HA, Albashir HB, Ali Mohamed Zain NQA, Abdelrahman Ibrahim ME, Ahmed Fadlallah EN.   +6 more
europepmc   +1 more source

Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target. [PDF]

Cancer Med
Zhang J, Liu C, Luo W, Sun B.
europepmc   +1 more source

Advanced pathological subtype classification of thyroid cancer using efficientNetB0. [PDF]

Diagn Pathol
Guo H, Zhang J, Li Y, Pan X, Sun C.
europepmc   +1 more source

Cost‐effectiveness analysis of postoperative surveillance for stage IV colorectal cancer in Japan: An economic modeling study

Annals of Gastroenterological Surgery, EarlyView.
This economic evaluation used a Markov state‐transition model to analyze the cost‐effectiveness of surveillance strategies recommended by various academic societies. This study found that the surveillance program proposed by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) was the most cost‐effective, with an incremental cost ...
Fumio Tsukamoto, Shunsuke Tsukamoto, Takeharu Kato, Hiroshi Nagata, Yasuyuki Takamizawa, Konosuke Moritani, Yusuke Kinugasa, Minoru Esaki, Yukihide Kanemitsu, Ataru Igarashi   +9 more
wiley   +1 more source