Results 181 to 190 of about 507,437 (241)

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

ATM is associated with the prognosis of colorectal cancer: a systematic review. [PDF]

Front Oncol
Wu P, Wen Z.
europepmc   +1 more source

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, EarlyView.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Neurological manifestations of Erdheim-Chester disease and their management: A scoping review. [PDF]

Medicine (Baltimore)
Qazi MS, Ahmad A, Mukhtiar M, Noor R, Ahmed H, Mehmood SU, Abbasi M, Siddiqui A, Hasanain M, Abideen ZU, Mahmmoud Fadelallah Eljack M.   +10 more
europepmc   +1 more source

Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study

Annals of Neurology, EarlyView.
Objective Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can improve individual survival predictions.
Isabelle Lajoie, Canadian ALS Neuroimaging Consortium (CALSNIC), Sanjay Kalra, Mahsa Dadar   +3 more
wiley   +1 more source

Role of the platelet-lymphocyte ratio as a prognostic indicator in patients with intracranial hemorrhage: A systematic review and meta-analysis. [PDF]

PLoS One
Yuan X, Zhang S, Wan J, Yang J, Deng Y, Feng Y, Bao Q, Liu X, Shen Y, Chen X, Zeng J, Zhang Y.   +11 more
europepmc   +1 more source

Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features

Annals of Neurology, EarlyView.
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). Methods Patients with POE recruited to an epilepsy genetics research program underwent phenotyping and genetic analysis. The latter included screening for rare pathogenic variants in epilepsy genes, and polygenic risk score (PRS) calculation for ...
Genevieve Rayner, Eliza Honybun, Melanie Bahlo, Karen L. Oliver, Ingrid E. Scheffer   +4 more
wiley   +1 more source

Prognostic significance of CD8 + tumor-infiltrating lymphocytes in operable breast cancer: a meta-analysis. [PDF]

BMC Cancer
Niu R, Wang C, Xie Y, Li S, Zhao Q, Chang Y, Mei Z.   +6 more
europepmc   +1 more source

Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

Annals of Neurology, EarlyView.
The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators.
Alison M. H. Donald, Luiz G. N. de Almeida, Mohamed Ziad Dabaja, Isabella Orchard, Kaia Ybema, Veronica Tsegai, Victoria Armstrong, Sophie Smith, Daniel Young, Richard Stewart Longman, Amanda V. Tyndall, Jean M. Rawling, Michael D. Hill, Willis H. Tsai, Ejaife Agbani, Marc J. Poulin, Antoine Dufour   +16 more
wiley   +1 more source

Prognostic Significance and Molecular Classification of Triple Negative Breast Cancer: A Systematic Review. [PDF]

Eur J Breast Health
Dogra AK, Prakash A, Gupta S, Gupta M.
europepmc   +1 more source