Results 141 to 150 of about 3,512,914 (385)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Grobner Bases for Nonlinear DAE Systems of Analog Circuits [PDF]

Computer Science Journal of Moldova, 2008
Systems of differential equations play an important role in modelling and analysis of many complex systems e.g. in electronics and mechanics. The following article is concerned with a symbolic analysis approach for reduction of the differential index of ...
Silke J. Spang
doaj  

The prognosis of major surgery for cancer in the aged [PDF]

, 1954
Thomas J. Anglem, Martin L. Bradford
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Enhanced Fatigue Crack Detection in Complex Structure with Large Cutout Using Nonlinear Lamb Wave

Sensors
The large cutout structure is a key component in the bottom skin of an airplane wing, and is susceptible to developing fatigue cracks under service loads.
Suofeng Zhang, Yuan Liu, Shenfang Yuan
doaj   +1 more source

Recent advances in understanding and managing psoriatic arthritis [version 1; referees: 2 approved]

F1000Research, 2016
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches.
Dafna D. Gladman
doaj   +1 more source

PATENT DUCTUS ARTERIOSUS SOME NOTES ON PROGNOSIS AND ON PULMONARY HYPERTENSION [PDF]

, 1955
Mark Campbell
openalex   +1 more source

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

New England Journal of Medicine, 2018
BACKGROUND Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates.
J. Grinfeld, J. Nangalia, J. Baxter, D. Wedge, Nicos Angelopoulos, R. Cantrill, A. Godfrey, E. Papaemmanuil, G. Gundem, C. Maclean, J. Cook, Laura O'Neil, S. O’Meara, J. Teague, A. Butler, C. Massie, N. Williams, Francesca L. Nice, C. Andersen, H. Hasselbalch, P. Guglielmelli, M. McMullin, A. Vannucchi, C. Harrison, M. Gerstung, A. Green, P. Campbell   +26 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The Diagnosis, Prognosis and Early Treatment of Poliomyelitis [PDF]

, 1922
NULL AUTHOR_ID
openalex   +1 more source