Results 151 to 160 of about 3,538,014 (404)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Guided Lamb Wave Array Time-Delay-Based MUSIC Algorithm for Impact Imaging

open access: yesSensors
Composite materials, valued in aerospace for their stiffness, strength and lightness, require impact monitoring for structural health, especially against low-velocity impacts.
Fei Zheng, Shenfang Yuan
doaj   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Implementation of Quality Assurance in Reproductive & Child Health Services Project in Maharashtra State

open access: yesNational Journal of Community Medicine, 2019
Introduction: Globally ‘quality health care’ and particularly the domain of Reproductive and Child Health (RCH) services attract substantial attention. United Nations Population Fund (UNFPA) implemented Quality Assurance in Reproductive and Child Health
Prakash P Doke, Abhijit R Khanvilkar
doaj  

Impact of Chronic Kidney Disease on the Processes of Care and Long‐Term Mortality of Non–ST‐Segment–Elevation Myocardial Infarction: A Nationwide Cohort Study and Long‐Term Follow‐Up

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A growing population of patients with chronic kidney disease (CKD) presents with non–ST‐segment–elevation myocardial infarction, although little is known about their longer‐term mortality.
Nicholas Weight   +10 more
doaj   +1 more source

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