Results 41 to 50 of about 1,715,562 (269)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Innovative Parkinson's Disease Patients' Motor Skills Assessment: The i-PROGNOSIS Paradigm

, 2020
Art. 20, 19 S.Being the second most common neurodegenerative disease, Parkinson's disease (PD) can be symptomatically treated, although, unfortunately, it cannot be cured yet. Moreover, diagnosing and assessing PD patients is a complex process, requiring
Theodoropoulou, Elina, Konstantinos Filis, Ntakakis, George, José Alves Diniz, Filis, Konstantinos, Bostantzopoulou, Sevasti, Ioakeimidis, Ioannis, Katsarou, Zoe, Sevasti Bostantzopoulou, Leontios J. Hadjileontiadis, Theodore Savvidis, Delopoulos, Anastasios, Gonçalo Telo, George Apostolidis, Dimitropoulos, Kosmas, Panagiotis D. Bamidis, Hoermann, Vera, Nikos Grammalidis, Grammatikopoulou, Athina, Papadopoulos, Alexandros, Fotis Karayiannis, Savvidis, Theodore, Athina Grammatikopoulou, Grammalidis, Nikos, Diniz, José A., Jaeger, Hagen, Sofia Balula Dias, Stelios Hadjidimitriou, K. Ray Chaudhuri, Hadjileontiadis, Leontios J., Karayiannis, Fotis, Dimitrios Iakovakis, Zilidou, Vicky, Vasileios Charisis, Hadjidimitriou, Stelios, George Ntakakis, Bamidis, Panagiotis, Konstantinos Kyritsis, Vicky Zilidou, Huchet, Estelle, Vera Hoermann, Heinz Reichmann, Iakovakis, Dimitrios, Estelle Huchet, Alexandros Papadopoulos, Hagen Jaeger, Silva, Hugo, Chaudhuri, Ray K., Lyberopoulos, George, Klingelhoefer, Lisa, Kosmas Dimitropoulos, Lisa Klingelhoefer, Elina Theodoropoulou, Apostolidis, George, Stadtschnitzer, Michael, Evdokimos Konstantinidis, Michael Stadtschnitzer, Konstantinidis, Evdokimos, Dhaval Trivedi, Charisis, Vasileios, Dias, Sofia B., Kyritsis, Konstantinos, Hugo Silva, Anastasios Delopoulos, Zoe Katsarou, Telo, Gonçalo, George Lyberopoulos, Ioannis Ioakeimidis, Trivedi, Dhaval, Reichmann, Heinz   +69 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Data-driven approach to machine condition prognosis using least square regression trees

, 2007
Machine fault prognosis techniques have been considered profoundly in the recent time due to their profit for reducing unexpected faults or unscheduled maintenance.
Tran, Van Tung
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers [PDF]

, 2009
Introduction: Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated ...
Pusztai, Laos, Solbach, Christine, Ahr, André, Karn, Thomas, Liedtke, Cornelia, Gätje, Regine, Hanker, Lars, Holtrich, Uwe, Gaetje, Regine, Rody, Achim, Ruckhäberle, Eugen, Metzler, Dirk, Ruckhaeberle, Eugen, Engels, Knut, Kaufmann, Manfred   +14 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source