Results 81 to 90 of about 2,487,520 (363)

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients

Biomarker Insights, 2016
Diabetes is a global endemic with rapidly increasing prevalence in both developing and developed countries. The American Diabetes Association has recommended glycated hemoglobin (HbA1c) as a possible substitute to fasting blood glucose for diagnosis of ...
Shariq I. Sherwani, H. Khan, Aishah A. Ekhzaimy, A. Masood, M. Sakharkar   +4 more
semanticscholar   +1 more source

A Miniaturized and Ultra-Low-Power Wireless Multi-Parameter Monitoring System with Self-Powered Ability for Aircraft Smart Skin

Sensors
The aircraft smart skin (ASS) with structural health monitoring capabilities is a promising technology. It enables the real-time acquisition of the aircraft’s structural health status and service environment, thereby improving the performance of the ...
Chongqi Wang, Yu Wang, Wei Pu, Lei Qiu
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Genome doubling shapes the evolution and prognosis of advanced cancers

Nature Genetics, 2018
Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients ...
C. Bielski, A. Zehir, A. Penson, M. Donoghue, W. Chatila, J. Armenia, Matthew T. Chang, A. Schram, P. Jonsson, C. Bandlamudi, P. Razavi, G. Iyer, M. Robson, Z. Stadler, N. Schultz, J. Baselga, D. Solit, D. Hyman, M. Berger, B. Taylor   +19 more
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Early Jurassic A-type granite and monzodiorite from the Baoji batholith: Implication for tectonic transition from post-collision to post-orogenic extension in the Qinling Orogenic Belt, China

Frontiers in Earth Science
Introduction: The early Jurassic granitoids in the Qinling Orogenic Belt (QOB) play a crucial role in understanding the tectonic implications for the geological evolution of China.
Xiangkuan Gong, Nijiati Abuduxun, Xiaoliang Jia, Yuanfeng Cheng, Hongming Cai, Xueqian Wu, Haodong Yang   +6 more
doaj   +1 more source

Impact Monitoring for Aircraft Smart Composite Skins Based on a Lightweight Sensor Network and Characteristic Digital Sequences

Sensors, 2018
Due to the growing use of composite materials in aircraft structures, Aircraft Smart Composite Skins (ASCSs) which have the capability of impact monitoring for large-scale composite structures need to be developed.
Lei Qiu, Xiaolei Deng, Shenfang Yuan, YongAn Huang, Yuanqiang Ren   +4 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Unsupervised adaptive feature enhancement network for reliable damage alarm using guided waves under time-varying conditions

International Journal of Smart and Nano Materials
Structural health monitoring technology is crucial for ensuring the safe operation and reducing maintenance cost of aircraft structures. But complex time-varying conditions, which contain multiple coupled service environment factors, will significantly ...
Fan Shao, Jiaxuan Li, Li Ouyang, Yuanqiang Ren, Lei Qiu, Shengfang Yuan   +5 more
doaj   +1 more source