Results 251 to 260 of about 757,160 (318)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Postmastectomy radiotherapy in pN1 breast cancer: Survival outcomes and prognostic factors from a single-institution cohort. [PDF]

PLoS One
Narasimhan RM, Saini AS, Samimi K, Ogobuiro I, Zhao X, Han S, Takita C, Taswell CS.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Characterization and Prognostic Factors of Severe Pediatric Traumatic Brain Injury. [PDF]

Cureus
De Beir J, César A, Moinho R, Pinto C, Carvalho L.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Which prognostic factors for recurrence after transanal endoscopic microsurgery for early rectal cancer? [PDF]

Surg Endosc
Arezzo A, Ammirati CA, Distefano G, Barbiero M, Sbuelz F, Passera R, Morino M.   +6 more
europepmc   +1 more source

Prognostic Factors and Clinical Outcomes in Critically Ill Patients with Hematological Malignancies in the Intensive Care Unit. [PDF]

J Clin Med
Yüksel RC, Kaynar AS, Metin H, Temel Ş, Baran Ünal C, Yılmaz Z, Akyol G, Gündoğan K, Sungur M.   +8 more
europepmc   +1 more source

Local Ablative Therapy in Breast Cancer Liver Metastases: Survival Outcomes and Prognostic Factors-A Single-Center Retrospective Study. [PDF]

J Clin Med
Sertesen Çamöz E, Bayrak A, Karaçin C, Törenek Ş, Deliktaş Onur İ, Önder T, Ateş Ö.   +6 more
europepmc   +1 more source

Prognostic Factors for Mortality in Patients with Pyogenic Liver Abscess: A Systematic Review and Meta-Analysis. [PDF]

Int J Med Sci
Lin JW, Ho TH, Shiang MC, Cheng HM, Lee YT, How CK, Hsu TF.   +6 more
europepmc   +1 more source