Results 131 to 140 of about 72,168 (304)

Prognostic

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Introduction: Severe community acquired pneumonia (SCAP) occurs in approximately 18–36% of all CAP and the mortality rate could be as high as 67% in patients with SCAP. Several studies have described a correlation between baseline lactate concentration and mortality of ICU patients.
Kamel Abd Elaziz Mohamed, Dief Abd Elgalil Ahmed   +1 more
openaire   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Real‐World Insights Into the Clinical Characteristics and Survival Outcomes of Extranodal Peripheral T‐Cell Lymphomas: A Multiethnic Asian Cohort Study

eJHaem
Background Extranodal peripheral T‐cell lymphomas (PTCLs) comprise a diverse group of lymphomas whose real‐world presentation and course are infrequently studied.
Ryan Yee Shien Neo, Esther Wei Yin Chang, Soon Thye Lim, Jason Yongsheng Chan   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Technical level estimation and prognostication of military-oriented aerotechnics standards [PDF]

, 2013
Розглянутий порядок оцінки та прогнозування технічного рівня перспективної авіаційної техніки за допомогою “Методики оцінки і прогнозування технічного рівня зразків авіаційної техніки військового призначення на основі комплексування їх ТТХ”.Рассмотрен ...
П.И. Нор, О.В. Кучурін, А.В. Коломийцев, P.I. Nor, О.В. Коломійцев, Д.Г. Васильєв, П.І. Нор, A.V. Kuchurin, Д.Г. Васильев, А.V. Kolomiycev, D.G. Vasiliev, А.В. Кучурин   +11 more
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prognostic

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: Significant portions of central airway stenosis patients present with unresectable disease. Using bronchotherapeutic procedures to maintain a patent airway and improve clinical symptoms and quality of life is a well-known armamentarium technique.
Rabieh M.M. Hussein, Emad El-Dine A. Korraa, M. Amany Fawzy, Ashraf E. Sileem   +3 more
openaire   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source