Results 111 to 120 of about 98,345 (305)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Correlates and Prognostic Value of Serial N‐Terminal Pro‐B‐Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiovascular biomarkers such as NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for heart failure risk stratification in patients with acquired heart disease, but there are limited data about its role in patients with ...
Ahmed Bahnasy, Meena Bai, Sara Aboelmaaty, Mohamed Ellabbad, William R. Miranda, Heidi M. Connolly, Allan S. Jaffe, Alexander C. Egbe   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Modeling the net value of a unit of pension assets in non-state pension funds

Економіка, управління та адміністрування
The pension system of Ukraine has three levels, the third level of which is represented by non-state pension funds (NPF) with different structures: corporate, professional and open.
I.V. Tarasov, L.M. Filipishyna
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Prognostication of Follicular Lymphoma: A Review of Prognostic Scores and Factors

Diagnostics
Follicular lymphoma (FL) is an indolent, rarely curable B-cell malignancy with a heterogeneous clinical course. While generally treatable, FL is characterized by remissions and relapses, and its clinical presentation varies widely.
Ádám Jóna, Evelin Kiss, Árpád Illés   +2 more
doaj   +1 more source

Методы прогнозирования управленческих решений на машиностроительных предприятиях [PDF]

, 2009
Статья посвящена проблемам прогнозирования экономических систем. В частности подробно рассматривается методология прогнозирования, кратко обозначается суть различных методов и приемов экономического прогнозирования.
Косенко, Александра Петровна, Перерва, Петр Григорьевич, Шевченко, Л. С.   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Piracy in Russia and China: A Different U.S. Reaction [PDF]

, 2000
Both Russia and China refused to adopt international copyright agreements until pressured by other countries, particularly the US. The US has pursued China\u27s copyright abuses more aggressively than it has pursued similar abuses by Russia.
Neigel, Connie
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source