Results 111 to 120 of about 72,168 (304)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
MedicinaBackground and Objectives: Static prognostication in comatose out-of-hospital cardiac arrest (OHCA) survivors may overlook delayed recovery, risking premature withdrawal of life-sustaining therapy (WLST).
Hyo Joon Kim +3 more
doaj +1 more source
Prognostication Events and Phenomena in Sport by the Spreadsheets of Мicrosoft Excel. [PDF]
, 2010 У статті розкрито зміст понять “ прогноз” і “ прогнозування”. Охарактеризовано основні методи прогнозування. Наведено прості та доступні прийоми прогнозування за допомогою електронних таблиць Мicrosoft Excel.
Романюк, В. П. +3 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
European Journal of Case Reports in Internal MedicineIntroduction: Bilateral fixed dilated pupils (BFDP) have traditionally been regarded as an ominous sign indicating severe brainstem dysfunction and poor neurological prognosis, often prompting discussions regarding withdrawal of life-sustaining treatment.
Sody A. Naimer
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Prognostication of Follicular Lymphoma: A Review of Prognostic Scores and Factors
DiagnosticsFollicular lymphoma (FL) is an indolent, rarely curable B-cell malignancy with a heterogeneous clinical course. While generally treatable, FL is characterized by remissions and relapses, and its clinical presentation varies widely.
Ádám Jóna +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Сеченовский вестник, 2015 The purpose is to determine the possibility of prognostication of the of acute odontogenic sinusitis development of the maxillary sinus based on the data of the index of leukocytes of blood change аnd determine its prognostic effi cacy in this nosology ...
I. O. Pokhodenko-Chudakova +1 more
doaj