Results 101 to 110 of about 20,102 (279)

Deployment of prognostics to optimize aircraft maintenance: A literature review

, 2019
Historic records show that the cost of operating and supporting an aircraft may exceed the initial purchase price as much as ten times. Maintenance, repair and overhaul activities represent around 10-15% of an airlines annual operational costs. Therefore,
Sprong, Jorben (author), Polinder, H. (author), Jiang, X. (author)   +2 more
core   +1 more source

A REVIEW: PROGNOSTICS AND HEALTH MANAGEMENT IN AUTOMOTIVE AND AEROSPACE

International Journal of Prognostics and Health Management, 2019
Prognostics and Health Management (PHM) attracts increasing interest of many researchers due to its potentially important applications in diverse disciplines and industries.
Van Duc Nguyen, Marios Kefalas, Kaifeng Yang, Asteris Apostolidis, Markus Olhofer, Steffen Limmer, Thomas Bäck   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Relibility enhance powertrain using ANFIS base prognostics model

, 2015
In the past decades power electronics have become more interested devices for underpinning research towards the feasibility of new generation of electrical vehicle (EV) which helping to reduce the reliance on fossil fuels.
Payam Soulatiantork, Suresh Perinpanayagam, Mohammad Samie, Alghassi, Alirza, Samie, Mohammad, FAIFER, MARCO, Perinpanayagam, Suresh, Marco Faifer, SOULATIANTORK, PAYAM, Alirza Alghassi   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Advancing a Non-Contact Structural and Prognostic Health Assessment of Large Critical Structures

Sensors
This paper presents an overview of integrating new research outcomes into the development of a structural health monitoring strategy for the floating cover at the Western Treatment Plant (WTP) in Melbourne, Australia.
Wing Kong Chiu, Thomas Kuen, Benjamin Steven Vien, Hugh Aitken, Louis Raymond Francis Rose, Matthias Buderath   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source