Results 41 to 50 of about 9,692 (263)

Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value

Frontiers in Cell and Developmental Biology, 2022
Colorectal liver metastases (CRLMs) are clinically heterogeneous lesions with poor prognosis. Genetic alterations play a crucial role in their progression.
Xuanwen Bao, Kun Wang, Ming Liu, Bin Li, Hongwei Wang, Kemin Jin, Xiaoluan Yan, Hangyu Zhang, Quan Bao, Da Xu, Lijun Wang, Wei Liu, Yanyan Wang, Juan Li, Lijuan Liu, Weijia Fang, Baocai Xing   +16 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Use of inpatient palliative care in metastatic testicular cancer patients undergoing critical care therapy: insights from the national inpatient sample

Scientific Reports
To test for rates of inpatient palliative care (IPC) in metastatic testicular cancer patients receiving critical care therapy (CCT). Within the Nationwide Inpatient Sample (NIS) database (2008–2019), we tabulated IPC rates in metastatic testicular cancer
Cristina Cano Garcia, Reha-Baris Incesu, Francesco Barletta, Simone Morra, Lukas Scheipner, Andrea Baudo, Stefano Tappero, Mattia Luca Piccinelli, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Carlo Terrone, Ottavio De Cobelli, Luca Carmignani, Sascha Ahyai, Nicola Longo, Derya Tilki, Alberto Briganti, Severine Banek, Luis A. Kluth, Felix K. H. Chun, Pierre I. Karakiewicz   +21 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Prognostics for Electromagnetic Relays Using Deep Learning

IEEE Access, 2022
Electromagnetic Relays (Electromagnetic Relay (EMR)s) are omnipresent in electrical systems, ranging from mass-produced consumer products to highly specialised, safety-critical industrial systems. Our detailed literature review focused on EMR reliability
Lucas Kirschbaum, Valentin Robu, Jonathan Swingler, David Flynn   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A New Method for Friction Estimation in EMA Transmissions

Actuators, 2021
The increasing interest for adopting electromechanical actuators (EMAs) on aircraft demands improved diagnostic and prognostic methodologies to be applied to such systems in order to guarantee acceptable levels of reliability and safety.
Gaetano Quattrocchi, Alessandro Iacono, Pier C. Berri, Matteo D. L. Dalla Vedova, Paolo Maggiore   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CTSL, a prognostic marker of breast cancer, that promotes proliferation, migration, and invasion in cells in triple-negative breast cancer

Frontiers in Oncology, 2023
IntroductionIn the world, the incidence of breast cancer has surpassed that of lung cancer, and it has become the first malignant tumor among women. Triple-negative breast cancer (TNBC) shows an extremely heterogeneous malignancy toward high recurrence ...
Lianmei Zhang, Lianmei Zhang, Lianmei Zhang, Yang Zhao, Jing Yang, Jing Yang, Yaning Zhu, Ting Li, Xiaoyan Liu, Pengfei Zhang, Jingliang Cheng, Suan Sun, Chunli Wei, Junjiang Fu   +13 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source