Results 51 to 60 of about 9,692 (263)

Uncertainty in Prognostics and Systems Health Management

International Journal of Prognostics and Health Management, 2015
This paper presents an overview of various aspects of uncertainty quantification and management in prognostics and systems health management. Prognostics deals with predicting possible future failures in different types of engineering systems.
Shankar Sankararaman, Kai Goebel
doaj   +1 more source

Implications of neuroendocrine tumor and diabetes mellitus on patient outcomes and care: a matched case–control study

Future Science OA, 2021
Aim: We aimed to determine the impact of diabetes mellitus (DM) on survival of patients with neuroendocrine tumors (NETs) and of NETs on glycemic control. Patients & methods: Patients with newly diagnosed NETs with/without DM were matched 1:1 by age, sex
Yael N Kusne, Heidi E Kosiorek, Matthew R Buras, Patricia M Verona, Kyle E Coppola, Kelley A Rone, Curtiss B Cook, Nina J Karlin   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Study on the Effectiveness of Time Series Similarity Measures for the Comparison of Degradation Curves of Similar Engineering Systems

IEEE Access
Data-driven methods have been shown to be suitable for the diagnosis and prognosis of the health of engineering systems. However, the training of data-driven methods usually requires a large amount of data, which is rarely available in industry.
Marcel Braig, Peter Zeiler
doaj   +1 more source

Controlling Tracking Performance for System Health Management - A Markov Decision Process Formulation

International Journal of Prognostics and Health Management, 2015
After an incipient fault mode has been detected a logical question to ask is: How long can the system continue to be operated before the incipient fault mode degrades to a failure condition?
Brian Bole, Kai Goebel, George Vachtsevanos   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A High Fidelity Model Based Approach to Identify Dynamic Friction in Electromechanical Actuator Ballscrews using Motor Current

International Journal of Prognostics and Health Management, 2018
An enhanced model based approach to monitor friction within Electromechanical Actuator (EMA) ballscrews using motor current is presented. The research was motivated by a drive in the aerospace sector to implement EMAs for safety critical applications to ...
Yameen M. Hussain, Stephen Burrow, Leigh Henson, Patrick Keogh   +3 more
doaj   +1 more source

Prognostic models

Practical Neurology, 2008
An appreciation of prognosis is essential for effective clinical practice, in neurology as in other fields. Predicting risk of a poor outcome in individuals, or at least in well-defined groups of individuals, is necessary to properly inform patients about what the future holds for them, and the likely benefits of treatment. Despite the various pitfalls
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source