Results 111 to 120 of about 9,895,757 (306)

The SURE Reliability Analysis Program [PDF]

open access: yes
The SURE program is a new reliability analysis tool for ultrareliable computer system architectures. The program is based on computational methods recently developed for the NASA Langley Research Center.
Butler, R. W.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Automatic Recognition and Replacement of Cyclic Redundancy Checks for Program Optimization

open access: yesIEEE Access
Cyclic redundancy check (CRC) is a fundamental error-detection mechanism widely used in digital networks and storage systems to ensure data integrity. CRC can be implemented in various ways.
Mariam Arutunian   +4 more
doaj   +1 more source

Program for analysis of nonlinear equilibrium and stability (PANES) [PDF]

open access: yes, 1975
PANES utilizes improved techniques for analysis of structures with material and geometric nonlinearities, including limit point and bifurcations behavior which occurs in buckling and collapse problems.
Vos, R. G.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Computer program simulates design, test, and analysis phases of sensitivity experiments [PDF]

open access: yes, 1967
Modular program with a small main program and several specialized subroutines provides a general purpose computer program to simulate the design, test and analysis phases of sensitivity experiments.
Alexander, M. J.   +2 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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