Results 141 to 150 of about 8,241,327 (286)

Sustainable and Active Program-Development and Application of SAVING Methodology. [PDF]

Int J Environ Res Public Health, 2022
Almeida-Silva M, Monteiro A, Carvalho AR, Teixeira AM, Moreira J, Tavares D, Tomás MT, Coelho A, Manteigas V.   +8 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Thermionic research and development program Final report [PDF]

Rhenium electrode material investigation and performance studies of low temperature cesium vapor thermionic ...
Campbell, A. E., Jackson, D. L.
core   +1 more source

Curriculum/program development in nursing education: a systematic review. [PDF]

BMC Nurs
Küçük Yüceyurt N, Kaya H.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Sakai Tutorials and User Guide [PDF]

, 2019
Instructional Technology Development Program (ITDP)
core   +1 more source

The Architecture of Decolonial Partnerships in University Global Health Program Development. [PDF]

Ann Glob Health
Crane S, Moralez AH, Diaz WF, Waldman B, Ansell D, Hernandez EM, Vlaming J, Dressel K, Young S, Kusinitz Z.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A technology development program for large space antennas [PDF]

The design and application of the offset wrap rib and the maypole (hoop/column) antenna configurations are described. The NASA mission model that generically categorizes the classes of user requirements, as well as the methods used to determine critical ...
Campbell, T. G., Freeland, R. E., Russell, R. A.   +2 more
core   +1 more source

Neonatal point-of-care ultrasound-steps for program development. [PDF]

J Perinatol
Bhombal S, Singh Y, Marshall S, Mukthapuram S, Fraga MV, National Neonatal POCUS Collaborative.   +5 more
europepmc   +1 more source