Results 191 to 200 of about 4,968,629 (297)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Strengthening family medicine through coaching-informed peer support: a pilot program evaluation. [PDF]

BMC Prim Care
Shuldiner J, Varkul O, Gnaneswaran T, Iqbal A, Szymanski K, Plenert E, Gill N, Smith SJ, Ramji N, Kim S, Tsang D, Kiran T, Ivers N.   +12 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Use of low-threshold naloxone boxes for opioid overdose prevention in a Midwestern US State: a public health program evaluation. [PDF]

Harm Reduct J
Lynch PS, Gamalski L, Roys V, Albers A, Burk K, Durán S, Facente SN.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nurse-led geriatric syndrome screening and intervention program for frail older inpatients in Singapore: a study protocol on implementation research and program evaluation. [PDF]

BMC Geriatr
Lim C, Ginting ML, Subramaniam A, Tang JY, Rodrigues EE, Chia JQ, Chua SY, Tan WS, Lim WS, Ding YY, Chew J, Sum G, INFA group.   +12 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Building a rural medical workforce: the foundations of a place-based approach to program evaluation. [PDF]

Front Med (Lausanne)
Fuller L, Beattie J, Versace VL, Rogers GD, McGrail MR.   +4 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Program Evaluation of the Family Adoption Program for Medical Graduates in India: A Strengths, Weaknesses, Opportunities and Challenges (SWOC) and Stakeholder Analysis in a Medical College in Assam. [PDF]

Cureus
Sharma S, Choudhari SG, Das D, Habib A, Ojah J.   +4 more
europepmc   +1 more source