Results 191 to 200 of about 24,429,365 (358)

Cartography of the Higher Education and Research System in France: Strategy, Programming, Evaluation, and Operational Units [PDF]

, 2019
Alves Baptista, Tatiane Tatiane
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

To the Editor: Innovation in Program Evaluation: The Development of a Logic Model for a Psychiatry Residency Training Program in Canada. [PDF]

J Grad Med Educ
Diep J, Zhang M, Ho C, Tan A, Chaukos D.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Assessing the Impact of an Indigenous Palliative Care Nurse Navigator: A Program Evaluation. [PDF]

Palliat Med Rep
McInnis IJ, Bablitz CA, Foster J, Morey T, Gougeon N, Quinn R.   +5 more
europepmc   +1 more source

Evaluation of a program to improve the capture efficiency of feeding traps

, 2013
Gouhei Ueda, Go Abe, Hiroshi Sakata
openalex   +1 more source

Reducing stress and supporting positive relations in families of young children with type 1 diabetes: A randomized controlled study for evaluating the effects of the DELFIN parenting program [PDF]

, 2012
Heike Saßmann, Mira de Hair, Thomas Danne, Karin Lange   +3 more
openalex   +1 more source

A case study of an academic‐stakeholder partnership: Evaluation of the ‘10 000 Lives’ smoking cessation health promotion program

, 2022
Arifuzzaman Khan, Kalie Green, Gulam Khandaker, Sheleigh Lawler, Coral Gartner   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Congenital glaucoma prevention program-Evaluation of patient knowledge and acceptance of genetic screening. [PDF]

J Genet Couns
Alizary A, AlTheeb A, Hameed S, Almadani B, Abualkhair S, Aljasim LA.   +5 more
europepmc   +1 more source