Results 1 to 10 of about 373,386 (221)

Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis. [PDF]

Molecules, 2023
This review uses the National Cancer Institute (NCI) COMPARE program to establish an extensive list of heterocyclic iminoquinones and quinones with similarities in differential growth inhibition across the 60-cell line panel of the NCI Developmental Therapeutic Program (DTP).
Haji N, Faizi M, Koutentis PA, Carty MP, Aldabbagh F.   +4 more
europepmc   +4 more sources

National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer. [PDF]

Cancer, 2019
Colorectal cancer (CRC) represents a major public health problem as the second leading cause of cancer‐related mortality in the United States. Of an estimated 140,000 newly diagnosed CRC cases in 2018, roughly one‐third of these patients will have a primary tumor located in the distal large bowel or rectum.
George TJ, Franke AJ, Chakravarthy AB, Das P, Dasari A, El-Rayes BF, Hong TS, Kinsella TJ, Landry JC, Lee JJ, Monjazeb AM, Jacobs SA, Raben D, Rahma OE, Williams TM, Wu C, Coleman CN, Vikram B, Ahmed MM.   +18 more
europepmc   +6 more sources

Growth in eligibility criteria content and failure to accrue among National Cancer Institute (NCI)-affiliated clinical trials. [PDF]

Cancer Med, 2023
AbstractBackgroundCancer trial accrual is a national priority, yet up to 20% of trials fail to accrue. Trial eligibility criteria growth may be associated with accrual failure. We sought to quantify eligibility criteria growth within National Cancer Institute (NCI)‐affiliated trials and determine impact on accrual.MethodsUtilizing the Aggregated ...
Peterson JS, Plana D, Bitterman DS, Johnson SB, Aerts HJWL, Kann BH.   +5 more
europepmc   +5 more sources

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks. [PDF]

ACS Omega, 2023
National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 ...
Evans JR, Akee RK, Chanana S, McConachie GD, Thornburg CC, Grkovic T, O'Keefe BR.   +6 more
europepmc   +3 more sources

Evaluation of the National Cancer Institute (NCI) Pathway to Independence Award (K99/R00) Program. [PDF]

J Cancer Educ
AbstractThe National Cancer Institute (NCI) K99/R00 award is intended to help postdoctoral scholars transition in a timely manner to research independence and to foster their development of an impactful cancer research program that is competitive for subsequent independent funding. Here we analyzed factors that impact peer review outcomes and evaluated
Schmidt M, Boulanger-Espeut C, Liou G, Ma N, Torres S, Cersosimo S, Bogler O, Zahir N.   +7 more
europepmc   +3 more sources

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. [PDF]

ACS Chem Biol, 2020
An automated, high-capacity, and high-throughput procedure for the rapid isolation and identification of biologically active natural products from a prefractionated library is presented. The semipreparative HPLC method uses 1 mg of the primary hit fraction and produces 22 subfractions in an assay-ready format.
Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR.   +12 more
europepmc   +4 more sources

Profiling mRNA, miRNA and lncRNA expression changes in endothelial cells in response to increasing doses of ionizing radiation

Scientific Reports, 2022
Recent and past research have highlighted the importance of the endothelium in the manifestation of radiation injury. Our primary focus is on medical triage and management following whole body or partial-body irradiation.
Sunita Chopra, Uma Shankavaram, Michelle Bylicky, Juan Dalo, Kevin Scott, Molykutty J. Aryankalayil, C. Norman Coleman   +6 more
doaj   +1 more source

Correction: Evaluation of the National Cancer Institute (NCI) Pathway to Independence Award (K99/R00) Program. [PDF]

J Cancer Educ
Schmidt M, Boulanger-Espeut C, Liou G, Ma N, Torres S, Cersosimo S, Bogler O, Zahir N.   +7 more
europepmc   +2 more sources

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Nature Communications, 2022
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix   +21 more
doaj   +1 more source

Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs

Scientific Reports, 2021
Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents.
Sunita Chopra, Maria Moroni, Jaleal Sanjak, Laurel MacMillan, Bernadette Hritzo, Shannon Martello, Michelle Bylicky, Jared May, C. Norman Coleman, Molykutty J. Aryankalayil   +9 more
doaj   +1 more source