Results 11 to 20 of about 373,386 (221)

Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Nature Communications, 2023
The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the ...
Tsion Zewdu Minas, Brittany D. Lord, Amy L. Zhang, Julián Candia, Tiffany H. Dorsey, Francine S. Baker, Wei Tang, Maeve Bailey-Whyte, Cheryl J. Smith, Obadi M. Obadi, Anuoluwapo Ajao, Symone V. Jordan, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Ann W. Hsing, Jia Liu, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs   +22 more
doaj   +1 more source

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters [PDF]

, 2010
Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known.
A Di Leonardo, A Kanhere, A Subramanian, AC Seila, AM Khalil, Anita Langerød, Anne-Lise Børresen-Dale, Ashley K Koegel, Benjamin Kong, C Bock, C Kosiol, Christopher Umbricht, CJ Sherr, CL Wei, David J Wong, DG Johnson, DJ Wong, E Pasmant, E Segal, F De Santa, G Hutvagner, G Michlewski, GA Calin, Gavin D Grant, Howard Y Chang, Hugo M Horlings, J Han, J Ponjavic, J Taylor, JC Schwartz, JL Rinn, JL Rinn, JM Morachis, JS Mattick, JS Mattick, JT Lee, K Struhl, KP Olive, L He, LJ Core, M Guttman, M Hall, M Huarte, Manolis Kellis, Marc van de Vijver, MC Tsai, MF Lin, MF Lin, Michael F Lin, Michael L Whitfield, MJ van de Vijver, ML Agarwal, ML Whitfield, Nilay Shah, OJ Rando, P Bertone, P Carninci, P Carninci, P Kapranov, Pei Wang, RA Gupta, RJ Taft, S Geisler, S Katayama, Saraswati Sukumar, Seung K Kim, Tiffany Hung, TK Kim, W Yu, X Wang, Yojiro Kotake, Yu Wang, Yue Xiong, Yulei Wang   +73 more
core   +6 more sources

GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas

Scientific Data, 2023
The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a prospective cohort study of nearly 155,000 U.S. volunteers aged 55–74 at enrollment in 1993–2001.
Mitchell J. Machiela, Wen-Yi Huang, Wendy Wong, Sonja I. Berndt, Joshua Sampson, Jonas De Almeida, Mustapha Abubakar, Jada Hislop, Kai-Ling Chen, Casey Dagnall, Norma Diaz-Mayoral, Mary Ferrell, Michael Furr, Alex Gonzalez, Belynda Hicks, Aubrey K. Hubbard, Amy Hutchinson, Kevin Jiang, Kristine Jones, Jia Liu, Erikka Loftfield, Jennifer Loukissas, Jerome Mabie, Shannon Merkle, Eric Miller, Lori M. Minasian, Ellen Nordgren, Brian Park, Paul Pinsky, Thomas Riley, Lorena Sandoval, Neeraj Saxena, Aurelie Vogt, Jiahui Wang, Craig Williams, Patrick Wright, Meredith Yeager, Bin Zhu, Claire Zhu, Stephen J. Chanock, Montserrat Garcia-Closas, Neal D. Freedman   +41 more
doaj   +1 more source

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era. [PDF]

, 2020
BackgroundFew adolescents and young adults (AYAs, 15-39 years old) enroll onto cancer clinical trials, which hinders research otherwise having the potential to improve outcomes in this unique population.
Blanke, Charles, Budd, Troy, Freyer, David R, Johnson, Rebecca H, Lewis, Mark A, O'Mara, Ann M, Pollock, Brad H, Roth, Michael E, Unger, Joseph M   +8 more
core   +2 more sources

An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA [PDF]

, 2008
A rigorous understanding of the biological function of superhelical tension in cellular DNA requires the development of new tools and model systems for study.
Ausubel F.M., Debra A. Dederich, Forterre P., Funnell B.E., Marita C. Barth, Peter C. Dedon   +5 more
core   +1 more source

Criteria for the use of omics-based predictors in clinical trials. [PDF]

, 2013
The US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to 'omics'-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based
A Dupuy, AM Molinaro, B Freidlin, Barbara A. Conley, David A. Eberhard, Deborah J. Shuman, HM Moore, J Subramanian, James H. Doroshow, James V. Tricoli, Jeremy M. G. Taylor, Jill P. Mesirov, JT Leek, Kelly Y. Kim, KK Dobbin, L Shi, Lisa M. McShane, LM McShane, Margaret M. Cavenagh, Mei-Yin C. Polley, P. Mickey Williams, R Simon, Richard M. Simon, RM Simon, Tracy G. Lively, William L. Bigbee   +25 more
core   +2 more sources

Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]

, 2018
NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B., Bougie, Danielle, Boxer, Matthew B., Brimacombe, Kyle R., Brown, Lauren E., Brown, M Kevin, Burns, Noah Z., Cha, Jin K., Cheff, Dorian M., Cheng, Ken, Clardy, Jon, Clement, Jason A., Coussens, Nathan P., Crooks, Peter A., Cuny, Gregory D., Dillon, Christopher, Dorjsuren, Dorjbal, Eastman, Richard T., Ganor, Jake, Garg, Neil K., Goess, Brian C., Grossman, Robert B., Guha, Rajarshi, Hall, Matthew D., Henderson, Mark J., Huang, Ruili, Hughes, Chambers C., Iannotti, Michael J., Inglese, James, Itkin, Zina, Jadhav, Ajit, Johnston, Jeffrey N., Joullie, Madeleine M., Karavadhi, Surendra, Kearney, Sara E., Kinghorn, A. Douglas, Kingston, David G. I., Klumpp-Thomas, Carleen, Krische, Michael J., Kwon, Ohyun, Lee, Tobie D., Lynch, Caitlin, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mevers, Emily E., Michael, Sam, Mohamed, Enas, Moreno, Jesus, Morrill, Lucas A., Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Picazo, Elias, Porco, John A., Ren, Tianjing, Rivas, Fatima, Rohde, Jason M., Ross, Samir A., Roth, Jacob S., Sakamuru, Srilatha, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Shen, Ben, Shen, Min, Shi, Wei, Shinn, Paul, Simeonov, Anton, Snyder, John K., Stephenson, Corey R. J., Sun, Wei, Susick, Robert B., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Titus, Steven A., Verano, Alyssa L., Vosburg, David A., Wan, Kanny K., Wu, Jimmy, Wuest, William M., Xia, Menghang, Xu, Zhengren, Yasgar, Adam, Zahoranszky-Kohalmi, Gergely, Zakarian, Armen, Zhang, Ya-Qin, Zhang, Yufeng, Zhao, Jinghua, Zhao, Tongan, Zheng, Wei, Zuo, Zhong   +94 more
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Pelvic exenteration and composite sacral resection in the surgical treatment of locally recurrent rectal cancer

Journal of the Egyptian National Cancer Institute, 2014
Background: The incidence of rectal cancer recurrence after surgery is 5–45%. Extended pelvic resection which entails En-bloc resection of the tumor and adjacent involved organs provides the only true possible curative option for patients with locally ...
Wael Gawad, Medhat Khafagy, Mohamed Gamil, Ibrahim Fakhr, Moustafa Negm, Nadia Mokhtar, Mohamed Lotayef, Osman Mansour   +7 more
doaj   +1 more source

RETRACTED ARTICLE: Predicting cancer prognosis and drug response from the tumor microbiome

Nature Communications, 2022
Tumor gene expression is predictive of patient prognosis in some cancers. However, RNA-seq and whole genome sequencing data contain not only reads from host tumor and normal tissue, but also reads from the tumor microbiome, which can be used to infer the
Leandro C. Hermida, E. Michael Gertz, Eytan Ruppin   +2 more
doaj   +1 more source

Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterations

npj Precision Oncology, 2023
Identifying patients that are likely to respond to cancer immunotherapy is an important, yet highly challenging clinical need. Using 3139 patients across 17 different cancer types, we comprehensively studied the ability of two common copy-number ...
Tian-Gen Chang, Yingying Cao, Eldad D. Shulman, Uri Ben-David, Alejandro A. Schäffer, Eytan Ruppin   +5 more
doaj   +1 more source