Results 231 to 240 of about 1,622,757 (315)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Engagement and retention in a motivational, discovery, and transitional track based substance use disorder recovery program: evaluation, facilitators and barriers. [PDF]

Subst Abuse Treat Prev Policy
Bunn TL, Thompson R, Ashworth M, Fletcher E.   +3 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Program Evaluation of the Family Adoption Program for Medical Graduates in India: A Strengths, Weaknesses, Opportunities and Challenges (SWOC) and Stakeholder Analysis in a Medical College in Assam. [PDF]

Cureus
Sharma S, Choudhari SG, Das D, Habib A, Ojah J.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Program Evaluation in Competence by Design: A Mixed-Methods Study. [PDF]

J Med Educ Curric Dev
Milosek J, Eady K, Moreau KA.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

CDC Program Evaluation Framework, 2024. [PDF]

MMWR Recomm Rep
Kidder DP, Fierro LA, Luna E, Salvaggio H, McWhorter A, Bowen SA, Murphy-Hoefer R, Thigpen S, Alexander D, Armstead TL, August E, Bruce D, Clarke SN, Davis C, Downes A, Gill S, House LD, Kerzner M, Kun K, Mumford K, Robin L, Schlueter D, Schooley M, Valverde E, Vo L, Williams D, Young K, CDC Evaluation Framework Work Group, CDC Evaluation Framework Work Group Members.   +28 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Co-design as a participatory approach for enhancing HPV health literacy among youths: a program evaluation. [PDF]

Ann Med
Dennehy J, Rauh L, Nahar K.
europepmc   +1 more source