Results 31 to 40 of about 2,660 (121)

Utilização da Linguagem de Programação Scratch na Aprendizagem de Funções do 1º Grau

, 2020
Este trabalho investiga as possÃveis contribuições da linguagem de programação Scratch na introdução do conceito de funções, em uma turma de 9º ano de uma escola pública estadual de Santa Catarina, Brasil. A pesquisa ação foi realizada durante os meses de março até maio de 2019 e teve duração de 20 encontros, num total de 30 horas, com ...
Riboldi, Sandra Mara Oselame, Richert, Janice Teresinha   +1 more
openaire   +1 more source

Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Seed amplification assays (SAAs) have shown promising results in detecting misfolded transactive response (TAR) DNA‐binding protein 43 (TDP‐43) in cerebrospinal fluid (CSF) of genetic frontotemporal dementia (FTD). To date, the use of SAA has yet to be evaluated in presymptomatic individuals.
Ilaria Linda Dellarole, Vittoria Aprea, Marcella Catania, Claudia Battipaglia, Aurora Romeo, Cristina Villa, Anna Burato, Luigi Celauro, Eleonora Dalla Bella, Nilo Riva, Erika Salvi, Giacomina Rossi, Giuseppe Di Fede, Giuseppe Legname, Julie F H De Houwer, Antonella Alberici, Barbara Borroni, Harro Seelaar, John C van Swieten, Fabio Moda, Paola Caroppo   +20 more
wiley   +1 more source

SESCTV: por uma transgressão pela linguagem

Rumores, 2008
O SESCTV, canal de televisão administrado pelo SESC (Serviço Social do Comércio de São Paulo), caracteriza-se como uma iniciativa peculiar em seu âmbito midiático.
Taís Rios Salomão de Souza
doaj   +1 more source

Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing‐Enabled Deep Brain Stimulation

Annals of Neurology, Volume 98, Issue 6, Page 1352-1363, December 2025.
Objective In Parkinson's disease (PD), the power of beta oscillations (± 13–30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations.
Martijn G.J. de Neeling, Bart J. Keulen, Mariëlle J. Stam, Deborah Hubers, Rob M.A. de Bie, Bernadette C.M. van Wijk, P. Rick Schuurman, Arthur W.G. Buijink, Martijn Beudel   +8 more
wiley   +1 more source

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%

European Journal of Neurology, Volume 32, Issue 12, December 2025.
This study investigated whether transmission ratio distortion (TRD) occurs in inherited prion diseases, specifically familial Creutzfeldt‐Jakob disease (p.E200K variant) and fatal familial insomnia (p.D178N variant), despite the theoretical 50% autosomal dominant inheritance risk.
Izaro Kortazar‐Zubizarreta, Africa Manero‐Azua, Hasier Eraña, Urko Aguire, Joaquín Castilla, Guiomar Perez de Nanclares   +5 more
wiley   +1 more source

The Global Impact of COVID‐19 Control Measures on People With Dementia Living at Home and Their Carers: A Systematic Review of Quantitative and Qualitative Research Across 27 Countries

Brain and Behavior, Volume 15, Issue 11, November 2025.
This graphical abstract summarizes the main findings of our systematic review about the global impacts of COVID‐19 control measures on people with dementia living at home and their carers : they were broadly consistent across regions. Our evidence synthesis highlights the critical need for decision‐makers to account for the needs of PWD and their ...
Yaohua Chen, Tatyana Mollayeva, Rachael Fitzpatrick, Thaisa Tylinski Sant'Ana, Francesca Farina, Dorota Swiatek, Kelli Sopidou, Evelyn Tabilo, Marta Betka, Iracema Leroi, Tomas Leon, Geeske Peeters, the STRAP consortium   +12 more
wiley   +1 more source

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome.
Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J. B. Vos, Mikel Tainta, Yvonne Freund‐Levi, Lutz Frölich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J. van der Lee, Philip Scheltens, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms   +26 more
wiley   +1 more source

A robótica livre e o ensino de física e de programação: desenvolvendo um teclado musical eletrônico / Free robotics and the teaching of Physics and programming: developing an electronic music keyboard

Texto Livre: Linguagem e Tecnologia, 2018
RESUMO: A Robótica tem sido utilizada em algumas pesquisas como recurso tecnológico inovador voltado para a Educação, de forma que a Robótica Livre vem contribuindo por ser mais acessível e permitir que as escolas possam trabalhar com essa tecnologia a ...
Thais Gabrielly Marques de Andrade, Zaíne Raquel Santos Vicente, Heryverton Araujo Lemos Leite, Ana Paula Chaves Cabral, Rodrigo Baldow, Nady Rocha, Marcelo Brito Carneiro Leão   +6 more
doaj   +1 more source

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyloid‐PET, including 622 with longitudinal data (3.66 ± 1.78 years).
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Mercè Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marquié, Anja Mett, Craig Ritchie, Gemma Salvadó, Michael Schöll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David Vállez García, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof   +37 more
wiley   +1 more source