Results 21 to 30 of about 404 (135)

SORL1 variant links endosomal amyloid precursor protein mis‐sorting to axonal transport defects and neuronal dysfunction

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer's disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional consequences of specific missense variants in human neurons remain unclear.
Miriam Lep, Klara Plesingrova, Jiri Sedmik, Sona Cesnarikova, Monica Feole, Ondrej Bernatik, Victorio Martin Pozo Devoto, Hana Hribkova, Katerina Amruz Cerna, Petr Fojtik, Nadezda Vaskovicova, Simona Bartova, Veronika Pospisilova, Tereza Vanova, Olav Michael Andersen, Dasa Bohaciakova, Jan Raska   +16 more
wiley   +1 more source

A Severity‐Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA‐Ataxia

Movement Disorders, Volume 41, Issue 8, Page 2143-2154, August 2026.
Background Spinocerebellar ataxia type 3 (SCA3) is a rare, inherited neurodegenerative disease characterized by progressive loss of motor coordination. Objectives We undertook a multisite magnetic resonance imaging study to profile the spatial spread of atrophy across the brain, determine whether atrophy preferentially maps onto specific functional ...
Jason W. Robertson, Isaac Adanyeguh, David J. Arpin, Tetsuo Ashizawa, Benjamin Bender, Fernando Cendes, Xi Chen, Giulia Coarelli, Léo Coutinho, Andreas Deistung, Imis Dogan, Alexandra Durr, Jennifer Faber, for the ESMI MR Study Group, Juan Fernandez‐Ruiz, Mónica Ferreira, Marcondes C. França, Sophia L. Göricke, Shuo Han, Thomas Klockgether, Chen Liu, Jun Luo, Alberto R.M. Martinez, Sergio E. Ono, Chiadi U. Onyike, Gülin Öz, for the EUROSCA MR Study Group, Henry Paulson, Jerry L. Prince, Kathrin Reetz, Thiago J.R. Rezende, Matthis Synofzik, Hélio A. Ghizoni Teive, Sophia I. Thomopoulos, Paul M. Thompson, Dagmar Timmann, David Vaillancourt, Bart van de Warrenburg, Judith van Gaalen, Xingang Wang, Philipp Wegner, Sarah H. Ying, Ian H. Harding, Carlos R. Hernandez‐Castillo   +43 more
wiley   +1 more source

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type
Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli   +22 more
wiley   +1 more source

Problemas com o uso de programação linear com posterior arredondamento da solução ótima, em regulação florestal

Revista Árvore, 2003
O principal objetivo deste trabalho foi avaliar, com a ajuda da Programação Inteira, as conseqüências do uso da Programação Linear com posterior arredondamento das respostas, com ênfase na regulação de florestas eqüiâneas.
Silva Gilson Fernandes da, Leite Helio Garcia, Silva Márcio Lopes da, Rodrigues Flávio Lopes, Santos Heleno do Nascimento   +4 more
doaj  

Linear programming model to optimize the water resource use in irrigation projects: an application to the Senator Nilo Coelho Project Modelo de programação linear para otimizar o uso da água em projetos de irrigação: uma aplicação ao projeto Senador Nilo Coelho

Scientia Agricola, 1997
The main objective of this paper was to develop a separable linear programming model, considering a set of technical factors which may influence the profit of an irrigation project The model presents an objective function that maximizes the net income ...
J.A. Frizzone, R.D. Coelho, D. Dourado-Neto, R. Soliani   +3 more
doaj   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

Gender responsiveness: Framing, programming, and the limits of transformative social protection in Ethiopia

International Social Security Review, Volume 79, Issue 2, Page 99-121, April/June 2026.
Gender responsiveness has emerged as a prominent concept in social protection policy, increasingly shaping donor agendas and national strategies. Yet despite widespread usage, we lack well‐defined analytical frameworks that allow for gender‐responsiveness assessments of entire national social protection systems.
Talea Grootenhuis
wiley   +1 more source

Otimização de problemas de roteamento de veículos: soluções heurísticas

CQD Revista Eletrônica Paulista de Matemática, 2020
Os custos com transporte e distribuição de produtos de um setor produtivo para seus locais de destino representam, geralmente, a maior parcela dos custos totais de produção.
Glaucia Maria Bressan, Luciene Aparecida de Oliveira Campos   +1 more
doaj  

Muscle MRI and Muscle Ultrasound Applications in MND/ALS: Academic Insights and Clinical Opportunities

European Journal of Neurology, Volume 33, Issue 3, March 2026.
ABSTRACT Background There is an unmet need for the clinically relevant ALS biomarkers to facilitate an accurate diagnosis in suspected cases, monitor disease progression and evaluate response to therapy in clinical trials. While the MND/ALS literature is dominated by innovative brain studies, motor disability in ALS is primarily driven by neurogenic ...
Alison Toomey, Jana Kleinerova, Ee Ling Tan, We Fong Siah, Peter Bede   +4 more
wiley   +1 more source

Algumas aplicações da análise limite numérica a problemas geotécnicos

Geotecnia, 2004
Várias formulações numéricas da análise limite têm sido propostas para a solução de problemas geotécnicos de estabilidade. Nestas formulações, o problema de estabilidade é colocado como um problema da Programação Matemálica.
Eurípedes Vargas Jr., Luiz Araújo, Aldo Farfan, Paulo Lemos, Luiz Vaz   +4 more
doaj   +1 more source