Results 21 to 30 of about 389 (135)
European Journal of Neurology, Volume 33, Issue 3, March 2026.ABSTRACT Background There is an unmet need for the clinically relevant ALS biomarkers to facilitate an accurate diagnosis in suspected cases, monitor disease progression and evaluate response to therapy in clinical trials. While the MND/ALS literature is dominated by innovative brain studies, motor disability in ALS is primarily driven by neurogenic ...
Alison Toomey +4 more
wiley +1 more source
Scientia Agricola, 1997 The main objective of this paper was to develop a separable linear programming model, considering a set of technical factors which may influence the profit of an irrigation project The model presents an objective function that maximizes the net income ...
J.A. Frizzone +3 more
doaj +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 854-867, March 2026.ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda +11 more
wiley +1 more source
Revista Árvore, 2003 O principal objetivo deste trabalho foi avaliar, com a ajuda da Programação Inteira, as conseqüências do uso da Programação Linear com posterior arredondamento das respostas, com ênfase na regulação de florestas eqüiâneas.
Silva Gilson Fernandes da +4 more
doaj
Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal +24 more
wiley +1 more source
Algumas aplicações da análise limite numérica a problemas geotécnicos
Geotecnia, 2004 Várias formulações numéricas da análise limite têm sido propostas para a solução de problemas geotécnicos de estabilidade. Nestas formulações, o problema de estabilidade é colocado como um problema da Programação Matemálica.
Eurípedes Vargas Jr. +4 more
doaj +1 more source
Glia, Volume 74, Issue 1, January 2026.C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli +12 more
wiley +1 more source
Otimização de problemas de roteamento de veículos: soluções heurísticas
CQD Revista Eletrônica Paulista de Matemática, 2020 Os custos com transporte e distribuição de produtos de um setor produtivo para seus locais de destino representam, geralmente, a maior parcela dos custos totais de produção.
Glaucia Maria Bressan +1 more
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Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.Abstract INTRODUCTION Currently, our ability to predict cognitive decline in Parkinson's disease is limited. METHODS In 234 dementia‐free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z‐score, health‐related quality of life (HR‐QoL), caregiver burden, and risk of ...
Saira S. Mirza +14 more
wiley +1 more source
O PROBLEMA DA DIETA E A APLICABILIDADE DA PESQUISA OPERACIONAL: RESULTADOS PRELIMINARES
Revista UniVap, 2017 A Pesquisa Operacional (PO) pode ser utilizada para resolver problemas como, por exemplo: alocação de serviços ou recursos, maximização de lucros, minimização de gastos, os quais são problemas encontrados no cotidiano.
Edilaine Barbosa do Amaral +2 more
doaj +1 more source