Results 41 to 50 of about 389 (135)

Otimização no planejamento agregado de produção em indústrias de processamento de suco concentrado congelado de laranja Optimization in the aggregate production planning in frozen concentrated orange juice processing industry

Gestão & Produção, 2010
Neste trabalho apresentam-se modelos de programação linear e programação por metas para apoiar decisões no processo de planejamento agregado da produção de suco concentrado congelado de laranja, com múltiplos produtos, estágios e períodos.
José Renato Munhoz, Reinaldo Morabito
doaj   +1 more source

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome.
Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J. B. Vos, Mikel Tainta, Yvonne Freund‐Levi, Lutz Frölich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J. van der Lee, Philip Scheltens, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms   +26 more
wiley   +1 more source

Um programa para o planejamento da recria de fêmeas oriundas de rebanhos leiteiros A computer program for planning dairy heifer raising

Revista de Economia e Sociologia Rural, 2002
Alimentação e manejo inadequados das novilhas em recria constituem alguns dos entraves ao incremento da produtividade do rebanho leiteiro no Brasil. Nessa fase, o pecuarista deve decidir entre recriar os animais de reposição, adquiri-los ou terceirizar ...
Moisés de Andrade Resende Filho
doaj   +1 more source

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyloid‐PET, including 622 with longitudinal data (3.66 ± 1.78 years).
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Mercè Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marquié, Anja Mett, Craig Ritchie, Gemma Salvadó, Michael Schöll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David Vállez García, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof   +37 more
wiley   +1 more source

Multiple Antibody‐Coated Gold Nanoparticle‐Based ExoAssay for Rapid Isolation of CNS‐Specific Exosomes From Blood

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
A streamlined nanowire‐based approach (ExoAssay) enabled direct, rapid, and cost‐effective isolation of neuronal extracellular vesicles (EVs) from human plasma using multiple antibody‐coated magnetic nanowires. The isolated EVs were characterized using nanoparticle tracking analysis (NTA), immunoblotting, and transmission electron microscopy (TEM ...
Leticia Camila Fernandez Flores, Neelam Younas, Stefan Goebel, Kathrin Dittmar, Tayyaba Saleem, Abrar Younas, Holger Budde, Tobias J. Legler, Wiebke Möbius, Peter Hermann, Matthias Schmitz, Inga Zerr   +11 more
wiley   +1 more source

PROCEDIMENTO PARA ANÁLISE ECONÔMICA EX-ANTE DA TERMINAÇÃO DE BOVINOS EM CONFINAMENTO

Informe Gepec, 2009
Esse artigo propõe um procedimento para a análise econômica ex-ante da terminação de bovinos em confinamentos para quando se fixa a priori a raça, peso inicial e número dos animais, a duração do confinamento e o tipo de instalações e benfeitorias, o que ...
Moisés A. Resende Filho
doaj   +1 more source

Understanding barriers and optimizing socio‐cognitive assessment in the diagnosis of neurocognitive disorders

Journal of Neuropsychology, Volume 19, Issue 3, Page 603-618, September 2025.
Abstract Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics. Neuropsychology assessments in NCDs seldom include tests exploring social cognitive skills. In 2022, we launched the SIGNATURE initiative to optimize socio‐cognitive assessment in NCDs.
Chiara Cerami, Marina Boccardi, Claudia Meli, Andrea Panzavolta, Giulia Funghi, Cristina Festari, Stefano F. Cappa, Thanos Chatzikostopoulos, Christian Chicherio, Florencia Clarens, Fabricio Ferreira de Oliveira, Francesco Di Lorenzo, Marco Filardi, Agustin Ibanez, Nicola Girtler, Thibaud Lebouvier, Giancarlo Logroscino, Antonella Luca, Sarah E. MacPherson, Jordi A. Matias‐Guiu, Tommaso Piccoli, Olivier Piguet, Simone Pomati, Mirella Russo, Leonardo Sacco, Ann‐Katrin Schild, Stefano L. Sensi, Steven D. Shirk, Marc Sollberger, Miguel Tábuas‐Pereira, Magda Tsolaki, Esther van den Berg, Maxime Bertoux, Fiona Kumfor, Jan Van den Stock, Kathleen A. Welsh‐Bohmer, Alessandra Dodich, on behalf of the SIGNATURE initiative   +37 more
wiley   +1 more source

Uma abordagem prática para a programação de setup e para o dimensionamento de lote em uma indústria têxtil A practical approach to lot and setup scheduling at a textile firm

Gestão & Produção, 1995
Estuda-se a programação de preparações de máquinas e atividades produtivas de uma indústria têxtil, localizada na Carolina do Norte, EUA. A firma enfrenta o problema de programar a produção das encomendas dos clientes em diversos teares circulares, que ...
Umit Akinc
doaj   +1 more source

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease‐modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment‐induced changes in ...
Takeshi Iwatsubo, Reisa A. Sperling, Alicia Algeciras‐Schimnich, Hidenori Arai, Anna M. Barron, Tammie L. S. Benzinger, Maria C. Carrillo, Christopher Chen, Seong Hye Choi, Igor C. Fontana, Jonathan Graff‐Radford, Joshua D. Grill, Judith Heidebrink, Chaur‐Jong Hu, Ryoko Ihara, Takeshi Ikeuchi, Atsushi Iwata, Fanny C. F. Ip, Fasihah Irfani Fitri, Clifford R. Jack Jr., Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, SangYun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton   +43 more
wiley   +1 more source

Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography—From Noise to Predictive Clinical Biomarker

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
Human brain pulsations shown in this picture drive both blood and CSF flow. These pulsations can now be accurately detected with ultrafast MREG imaging. The ultrafast imaging offers early detection of abnormal brain pulsations that can precede tissue degeneration in Alzheimer's disease or predict mortality in brain lymphoma treatment. ABSTRACT Over the
Vesa Kiviniemi, Heta Helakari, Lauri Raitamaa, Niko Huotari, Zalan Rajna, Matti Järvelä, Ahmed Elabasy, Johanna Tuunanen, Valter Poltojainen, Tommi Väyrynen, Timo Tuovinen, Janne Kananen, Vesa Korhonen   +12 more
wiley   +1 more source