Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Beneficis de l'envelliment actiu en la memòria; realitat o utopia? Incidència de l'activitat quotidiana en la memòria de treball [PDF]
, 2016 A través d'aquest estudi es cerquen les possibles diferències entre ancians actius i no actius pel que fa al seu rendiment en tasques de memòria de treball i, per tant, estudiar la importància que pren l'envelliment actiu en un millor manteniment de la ...
Insa Montero, Elisabet +1 more
core
Guia pràctica per fer un bon treball de recerca (TR) a batxillerat. #20 consells essencials [PDF]
, 2021 La navegació per aquest document està optimitzada quan s'obre directament amb el navegador Chrome o des d'Acrobat Reader; en canvi, presenta alguna deficiència si s'obre directament des dels navegadors Firefox o Safari.Edicions: 1a Edició de 2017 i 2a ...
Pons, Amadeu +4 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial. [PDF]
Int J Behav Nutr Phys Act, 2022 Gómez-Martínez C +15 more
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome? [PDF]
Depress Anxiety, 2023 Paz-Graniel I +48 more
europepmc +1 more source
Notes al voltant de la informació a Orient Mitjà [PDF]
, 1995 Notes al voltant de la informació a Orient ...
Alcoverro, Tomàs
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source