Results 51 to 60 of about 907 (261)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Ce que coder veut dire : y a-t-il un langage de programmation ?

open access: yesFrench Journal for Media Research, 2016
Même si le terme « langage de programmation » procède d’une métaphore, les sciences sociales pourraient avoir intérêt à considérer que le code informatique est effectivement un langage.
Sire Guillaume
doaj  

Metro Al Madina : une continuité artistique face à l’instabilité géopolitique libanaise

open access: yesPercées
Metro Al Madina (Le métro de la ville) est un espace culturel situé à Beyrouth, la capitale libanaise. Depuis 2012, il propose une programmation diversifiée mêlant cabaret, théâtre et musique.
Rawan Kachmar, Hisham Jaber
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effects of Video-Based Instructional Strategy (VBIS) on Junior Secondary School Students' Achievement in Computer Programming in Lagos State, Nigeria

open access: yesWest African Journal of Open and Flexible Learning, 2020
This study determined the effects of Video-Based Instructional Strategy (VBIS) on students' achievement in computer programming among junior secondary school students in Lagos State, Nigeria.
Adetunmbi L. Akinyemi   +1 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Absentes ou invisibles ? Les femmes dramaturges dans le programme « Registres de la Comédie-Française » (xviie-xviiie siècles)

open access: yesPratiques & Formes Littéraires 16-18
Cette contribution prend acte d’un impensé originel du programme en humanités numériques Registres de la Comédie-Française : dans la base initiale, la métadonnée « genre » a été omise, si bien qu’il est impossible de faire des requêtes ...
Sara Harvey, Tiphaine Karsenti
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

L'encyclopédie collective.

open access: yesEspacesTemps.net, 2004
En 1995, alors qu'Internet était encore très peu utilisé, Ward Cunningham développe un dispositif intitulé Wiki, en référence au mot hawaïen wikiwiki qui signifie « rapide ».
Boris Beaude
doaj  

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