Results 31 to 40 of about 212,261 (301)

PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. [PDF]

, 2016
A new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1).
Booton, R, Cane, P, Cree, IA, Gosney, J, Ibrahim, M, Kerr, K, Lal, R, Lewanski, C, Navani, N, Nicholson, AG, Nicolson, M, Summers, Y   +11 more
core   +2 more sources

Prognostic prospect of soluble programmed cell death ligand-1 in cancer management [PDF]

Acta Biochimica et Biophysica Sinica, 2021
Aggressive tissue biopsy is commonly unavoidable in the management of most suspected tumor cases to conclusively verify the presence of cancerous cells through histological assessment. The extracted tissue is also immunostained for detection of antigens (tissue tumor markers) of potential prognostic or therapeutic importance to assist in treatment ...
Nur Amira, Khairil Anwar, Muhammad Najmi, Mohd Nazri, Ahmad Hafiz, Murtadha, Elis Rosliza, Mohd Adzemi, Venugopal, Balakrishnan, Khairul Mohd Fadzli, Mustaffa, Tengku Ahmad Damitri Al-Astani, Tengku Din, Maya Mazuwin, Yahya, Juhara, Haron, Noor Fatmawati, Mokshtar   +9 more
openaire   +2 more sources

A comparative study to assess the increased expression of programmed cell death-1 (PD1) and programmed cell death- ligand-1 (PDL1) in oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Programmed cell death-1 (PD-1) is expressed on the surface of activated T cells, while its ligand, PD-L1, is expressed on the surface of dendritic cells or macrophages. Objective: This study assessed the increased expression of PD-1 and PD-L1
Sonalika Srivastava, Abhishek Sinha, Sunita Srivastava, Anuj Mishra   +3 more
doaj   +1 more source

Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis [PDF]

, 2014
INTRODUCTION: A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections.
Andriani C Patera, Bryan Sato, Catherine Svabek, Cristina Vazquez-Guillamet, David Rasche, JoAnn Suzich, Jonathan Green, Katherine Chang, Nancy Ulbrandt, Paul Robbins, Richard Hotchkiss, Strother Wilson, Subramaniam Krishnan, Wade Blair   +13 more
core   +2 more sources

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. [PDF]

, 2020
PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade.
Algazi, Alain P, Andtbacka, Robert HI, Arlauckas, Sean P, Ballesteros-Merino, Carmen, Bannavong, Donna, Bhatia, Shailender, Bifulco, Carlos, Browning, Erica, Canton, David A, Daud, Adil I, Fong, Lawrence, Fox, Bernard A, Francisco, Murray, Gargosky, Sharron, Garris, Christopher, Hermiz, Reneta, Le, Mai, Levine, Lauren P, Oglesby, Arielle, Pierce, Robert, Pittet, Mikael J, Rosenblum, Michael D, Tsai, Katy K, Twitty, Christopher G   +23 more
core   +2 more sources

Predictive Values of Programmed Cell Death-Ligand 1 Expression for Prognosis, Clinicopathological Factors, and Response to Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors in Patients With Gynecological Cancers: A Meta-Analysis

Frontiers in Oncology, 2021
BackgroundThe prognostic value of programmed cell death-ligand 1 (PD-L1) in gynecological cancers has been explored previously, but the conclusion remains controversial due to limited evidence.
Chen Zhang, Qing Yang
doaj   +1 more source

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells [PDF]

, 2018
CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death-1 receptor (PD-1) signaling imparted regulatory phenotype to ...
Amarnath, Shoba, Berlinguer-Palmini, Rolando, Bogyo, Matthew, Eckhaus, Michael A., Edgington-Mitchell, Laura, Felizardo, Tania C., Flomerfelt, Francis A., Fowler, Daniel H., Gangaplara, Arunakumar, Knight, David, Laurence, Arian, Liniany, Lukasz P., Mallett, Grace, Martinez-Fabregas, Jonathan, Samsel, Leigh A., Shevach, Ethan M., Stathopoulou, Chaido, van Kasteren, Sander I., Watts, Colin, Yim, Joshua J., Zhu, Jinfang   +20 more
core   +2 more sources

Programmed cell death-ligand 1 assessment in urothelial carcinoma: prospect and limitation [PDF]

Journal of Pathology and Translational Medicine, 2021
Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibition has revolutionized the treatment paradigm of urothelial carcinoma (UC). Several PD-L1 assays are conducted to formulate appropriate treatment decisions for PD-1/PD-L1 target therapy in UC.
Kyu Sang Lee, Gheeyoung Choe
openaire   +3 more sources

Elevated serum soluble programmed cell death ligand 1 concentration as a potential marker for poor prognosis in small cell lung cancer patients with chemotherapy

Respiratory Research, 2018
Background Potential relationship between serum soluble programmed cell death ligand 1 and prognosis of small cell lung cancer is not well explored. The aim of the study was to reveal the prognostic significance of serum soluble programmed cell death ...
Jianjun Jin, Jiming Si, Yuanhua Liu, Huanqin Wang, Ran Ni, Jing Wang   +5 more
doaj   +1 more source

Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications

Frontiers in Pharmacology, 2022
Introduction: In the tumor microenvironment, interferon gamma (IFN-γ) secreted by tumor infiltrating lymphocytes can upregulate programmed cell death 1 ligand 1 (PD-L1) expression in many cancers.
Libin Guo, Libin Guo, Xiaoqiong Tang, Xiaoqiong Tang, Sin Wa Wong, Anyuan Guo, Yao Lin, Yao Lin, Hang Fai Kwok, Hang Fai Kwok   +9 more
doaj   +1 more source