Results 1 to 10 of about 15,144 (118)

THE PD-1/B7-H1-MEDIATED PRO-APOPTOTIC ACTIVITY OF DENDRITIC CELLS AS A POSSIBLE MECHANISM OF ANTIGEN-SPECIFIC RESPONSE FAILURE IN PATIENTS WITH PULMONARY TUBERCULOSIS

Medical Immunology (Russia), 2014
Abstract. The aim of present study was to investigate PD-1/B7-H1-mediated induction of T-cell apoptosis/ anergy, a suggested mechanism of reduced antigen-specific immune response against M. tuberculosis. We examined 76 patients with pulmonary tuberculosis (PT) who differed in levels of proliferative response to specific antigen (purified protein ...
L. V. Sakhno, M. A. Tikhonova, T. V. Tyrinova, O. Yu. Leplina, S. D. Niconov, O. A. Zhdanov, A. A. Ostanin, E. R. Chernykh   +7 more
openaire   +4 more sources

B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets [PDF]

Journal of Clinical Investigation, 2014
Classical IL-22-producing T helper cells (Th22 cells) mediate inflammatory responses independently of IFN-γ and IL-17; however, nonclassical Th22 cells have been recently identified and coexpress IFN-γ and/or IL-17 along with IL-22. Little is known about how classical and nonclassical Th22 subsets in human diseases are regulated.
Dong-Ming, Kuang, Xiao, Xiao, Qiyi, Zhao, Min-Min, Chen, Xue-Feng, Li, Rui-Xian, Liu, Yuan, Wei, Fang-Zhu, Ouyang, Dong-Ping, Chen, Yan, Wu, Xiang-Ming, Lao, Hong, Deng, Limin, Zheng   +12 more
openaire   +2 more sources

Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistence [PDF]

Laboratory Investigation, 2016
B7-H1 binding to programmed death-1 may deliver a coinhibitory signal to T cells that is involved in the regulation of T-cell activation and tolerance. B7-H1 plays a key role in dysfunction of dendritic cells (DCs) during chronic HBV infection, but the expression mechanism of B7-H1 remains unclear.
Man, Li, Zhen-Hua, Zhou, Xue-Hua, Sun, Xin, Zhang, Xiao-Jun, Zhu, Shu-Gen, Jin, Ya-Ting, Gao, Yun, Jiang, Yue-Qiu, Gao   +8 more
openaire   +2 more sources

Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro

OncoTargets and Therapy, 2014
The aim of this study was to examine whether short hairpin RNA (shRNA) expressing lentiviral particles targeting B7-H1 infection could result in B7-H1 knockdown on dendritic cells (DCs) and to investigate whether B7-H1 silencing could augment the immune function of DCs and further elicit a more potent anti-tumor immune effect against bladder cancer ...
Wang,Shuo, Wang,Yonghua, Liu,Jing, Shao,Shixiu, Li,Xianjun, Gao,Jiannan, Niu,Haitao, Wang,Xinsheng   +7 more
openaire   +4 more sources

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

Blood, 2010
Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance.
Fukaya, Tomohiro, Takagi, Hideaki, Sato, Yumiko, Sato, Kaori, Eizumi, Kawori, Taya, Honami, Shin, Tahiro, Chen, Lieping, Dong, Chen, Azuma, Miyuki, Yagita, Hideo, Malissen, Bernard, Sato, Katsuaki   +12 more
openaire   +3 more sources

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus. [PDF]

iScience
Xiao ZX, Liang R, Hu X, Huang C, Nie J, Xie C, Wang J, Fang Q, Fan X, Olsen N, Zhou L, Li B, Zheng SG.   +12 more
europepmc   +1 more source

B7-H4: a multifaceted immune checkpoint and oncoprotein in cancer biology and immunotherapy. [PDF]

Front Immunol
Zhang C, Miao Z, Cao J, Wang X, Shi T.
europepmc   +1 more source

Igniting cold tumors: reprogramming the tumor immune microenvironment with dual-payload ADCs in combination with PD-L1&4-1BB bispecific antibodies. [PDF]

J Immunother Cancer
Pan J, Yuan X, Yu H, Liu Z, Chen S, Zhu F, Shang Y, Hong S, Han X, Zhu Z, Jin T, Pan Y, Zhou S.   +12 more
europepmc   +1 more source

Development and characterization of a novel B7-H3 rabbit monoclonal antibody for glioma diagnosis. [PDF]

Front Pharmacol
Li Y, Wang Z, Wen Q, Chiu M, Jia X, Li Y, Shang X.   +6 more
europepmc   +1 more source

Identification of Plasma Biomarkers for B7 Family Members Associated With Primary Sjögren's Syndrome. [PDF]

Immun Inflamm Dis
Song S, Yang Y, Shen Y, Ren T, Sun Z, Liu C.   +5 more
europepmc   +1 more source