Медицинская иммунология, 2014 . The aim of present study was to investigate PD-1/B7-H1-mediated induction of T-cell apoptosis/ anergy, a suggested mechanism of reduced antigen-specific immune response against M. tuberculosis.
L. V. Sakhno +7 more
doaj +3 more sources
Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy. [PDF]
Cancer InnovImmunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Yaacoub K.
europepmc +2 more sources
Engineered CAR-T-Derived Exosomes Co-Delivering miR-145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy. [PDF]
J Extracell VesiclesABSTRACT Chimeric antigen receptor T cell (CAR‐T) therapy has demonstrated remarkable efficacy in haematologic malignancies but remains constrained in solid tumours due to limited tumour penetration, immunosuppressive microenvironments and the risk of cytokine release syndrome (CRS).
Yang R +10 more
europepmc +2 more sources
Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Chang Hyun Nam +9 more
doaj +1 more source
Human Rhinovirus Infection Enhances the Th2 Environment in Allergic and Non-allergic Patients with Chronic Rhinosinusitis [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives. This study was conducted to determine whether patients with allergic rhinitis might be more susceptible to human rhinovirus (HRV) infection and whether the effects of infection on the elicited immune responses are different in allergic and ...
Young-Kyung Ko +5 more
doaj +1 more source
EFFECT OF TRANSFORMING GROWTH FACTOR β1 ON PROLIFERATION AND MIGRATION ABILITY OF BLADDER CANCER CELLS AND ITS MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the effect of transforming growth factor β1 (TGF-β1) on the proliferation and migration ability of bladder cancer T24 cells and its mechanism. Methods T24 cells were treated with TGF-β1 at concentrations of 0, 1, 5, 10, 20 and 40
CHEN Xinlei, YU Yongbo, LI Peng, NIU Haitao
doaj +1 more source
Alternative immune checkpoints in immunoregulatory profile of cancer stem cells
Heliyon, 2023 Tumor-mediated bypass of immune checkpoint inhibitor (ICI) therapy with anti-programmed death-1 (PD-1), anti-programmed death-ligand 1 (PD-L1, also called B7–H1 or CD274) or anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a challenge of ...
Keywan Mortezaee, Jamal Majidpoor
doaj +1 more source
B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets [PDF]
Journal of Clinical Investigation, 2014 Classical IL-22-producing T helper cells (Th22 cells) mediate inflammatory responses independently of IFN-γ and IL-17; however, nonclassical Th22 cells have been recently identified and coexpress IFN-γ and/or IL-17 along with IL-22. Little is known about how classical and nonclassical Th22 subsets in human diseases are regulated.
Dong-Ming, Kuang +12 more
openaire +2 more sources
CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. [PDF]
PLoS ONE, 2011 The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability, are now appreciated for their role in initiating and
D'Anne S Duncan, Stephen D Miller
doaj +1 more source
B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. [PDF]
PLoS Pathogens, 2009 Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are ...
Trupti Joshi +4 more
doaj +1 more source