Медицинская иммунология, 2014 . The aim of present study was to investigate PD-1/B7-H1-mediated induction of T-cell apoptosis/ anergy, a suggested mechanism of reduced antigen-specific immune response against M. tuberculosis.
L. V. Sakhno +7 more
doaj +3 more sources
Strategy for modular assembly of tetravalent, multispecific antibodies. [PDF]
Protein SciAbstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Mallette E +12 more
europepmc +2 more sources
Targeting WDR12 Unleashes T-Cell-Mediated Antitumor Activity in Melanoma by Destabilizing CD276. [PDF]
Adv Sci (Weinh)WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Pan J +10 more
europepmc +2 more sources
Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy. [PDF]
Cancer InnovImmunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Yaacoub K.
europepmc +2 more sources
Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer.
Chang Hyun Nam +9 more
doaj +1 more source
Human Rhinovirus Infection Enhances the Th2 Environment in Allergic and Non-allergic Patients with Chronic Rhinosinusitis [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives. This study was conducted to determine whether patients with allergic rhinitis might be more susceptible to human rhinovirus (HRV) infection and whether the effects of infection on the elicited immune responses are different in allergic and ...
Young-Kyung Ko +5 more
doaj +1 more source
EFFECT OF TRANSFORMING GROWTH FACTOR β1 ON PROLIFERATION AND MIGRATION ABILITY OF BLADDER CANCER CELLS AND ITS MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the effect of transforming growth factor β1 (TGF-β1) on the proliferation and migration ability of bladder cancer T24 cells and its mechanism. Methods T24 cells were treated with TGF-β1 at concentrations of 0, 1, 5, 10, 20 and 40
CHEN Xinlei, YU Yongbo, LI Peng, NIU Haitao
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Alternative immune checkpoints in immunoregulatory profile of cancer stem cells
Heliyon, 2023 Tumor-mediated bypass of immune checkpoint inhibitor (ICI) therapy with anti-programmed death-1 (PD-1), anti-programmed death-ligand 1 (PD-L1, also called B7–H1 or CD274) or anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a challenge of ...
Keywan Mortezaee, Jamal Majidpoor
doaj +1 more source
B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets [PDF]
Journal of Clinical Investigation, 2014 Classical IL-22-producing T helper cells (Th22 cells) mediate inflammatory responses independently of IFN-γ and IL-17; however, nonclassical Th22 cells have been recently identified and coexpress IFN-γ and/or IL-17 along with IL-22. Little is known about how classical and nonclassical Th22 subsets in human diseases are regulated.
Dong-Ming, Kuang +12 more
openaire +2 more sources
CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. [PDF]
PLoS ONE, 2011 The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability, are now appreciated for their role in initiating and
D'Anne S Duncan, Stephen D Miller
doaj +1 more source