Results 31 to 40 of about 545,026 (158)

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

B7-H1 expression in AGS cells after treatment with mimics or inhibitors of miR-152 and miR-200b.

, 2017
(A) AGS cells were transfected with various miRNA mimics for 48 h, and the cells with surface B7-H1 expression were sorted by flow cytometry. (B) AGS cells were treated with various miRNA inhibitors for 48 h, and the cells containing surface B7-H1 ...
Wei Li (7081), Ruidong Li (331648), Ke Wu (320733), Ende Zhao (3617516), Yuping Yin (3617510), Gengchen Xie (3617513), Yu Zhang (12946), Peng Zhang (2071), Liang Shi (8078), Rui Deng (157986), Kaixiong Tao (281715), Di Wang (329735)   +11 more
core   +1 more source

B7-H1 Expression in Malignant Pleural Mesothelioma is Associated with Sarcomatoid Histology and Poor Prognosis [PDF]

, 2014
Introduction:B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types.
Kwon, Eugene D., Peikert, Tobias, Krco, Christopher J., Dong, Haidong, Mansfield, Aaron Scott, Roden, Anja C., Sheinin, Yuri M., Harrington, Susan M.   +7 more
core   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin Carcinogenesis

, 2011
B7-H1 (CD274), a member of the B7 family of coinhibitory molecules, is often induced in human tumors and its expression is closely correlated with a poor prognosis or higher malignancy grade.
Pornpan Youngnak-Piboonratanakit, Fumihiko Tsushima, Masaaki Hashiguchi, Pacharee Ritprajak, Lu Zhang, Yosuke Kamimura, Miyuki Azuma, Yujia Cao   +7 more
core   +1 more source

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

, 2018
Development of resistance to chemotherapy is a major obstacle in extending the survival of patients with cancer. Although originally defined as an immune checkpoint molecule, B7-H1 (also named as PD-L1 or CD274) was found to play a role in cancer ...
Chunhua Chen, Tiancheng Xie, Yanli Li, Aaron S. Mansfield, Siyu Cao, Yiyi Yan, Liewei Wang, Xiaosheng Wu, Susan M. Harrington, Tu Pham, Eugene D. Kwon, Xin Liu, Kun Ling, Haidong Dong   +13 more
core   +1 more source

Effective knockdown of B7-H1 by siRNA in HCT116 cells.

, 2013
(A) RT-qPCR analysis to show the B7-H1 mRNA level. Parental or HCT116 cells transfected with scrambled siRNA or siRNA targeting B7-H1 for 48 h were harvested and RT-qPCR was performed; (B) Western blot analysis to detect the B7-H1 protein level. Parental
Ming Wei (466751), Yan-Ling Meng (138028), Li-Juan Wang (444194), Guo-Dong Wang (198564), An-Gang Yang (138039), Wei-Hong Wen (149933), Zhang-Yan Guo (466750), Sheng-Jia Shi (466749)   +7 more
core   +1 more source

Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma. [PDF]

, 2016
In order to evaluate the correlation of B7-H4 and B7-H1 with renal cell carcinoma (RCC), we analyzed B7-H1 and B7-H4 expressions and their clinical significance by immunohistochemical method. Our result indicated that B7-H4-positive staining was detected
Rostamzadeh, Ayoob., Rahmani, Omid., Yahaghi, Hamid., Mohammadi, Mohsen., Ahmadi, Koorosh., Ghaderi, Omar., Safaei, Hamid Reza.   +6 more
core   +1 more source

PD‐L1 in Ovarian Cancer: Immune Evasion, Tumor‐Intrinsic Signaling, and Chemoresistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
The “Dual Shield” model of PD‐L1 in ovarian cancer. On the outside, PD‐L1 engages PD‐1 to inactivate T cells and drive immune evasion (immune shield). Inside the tumor cell, PD‐L1 activates AKT–mTOR, enhances DNA repair, rewires metabolism, supports autophagy, and enforces stemness programs—collectively creating a chemoresistance shield.
Zhiyang Xu, Xiaohui Lv, Yunping Wang, Yanjie Ren   +3 more
wiley   +1 more source

B7-H1 inhibits T cell proliferation through MHC class II in human mesenchymal stem cells.

, 2014
B7-H1 on mesenchymal stem cells (MSCs) is known to modulate immune response. However, its expression pattern and exact immunomodulatory mechanism are unclear. In this study, we examined the immunomodulatory mechanism through the expression
Yoon, HH, Yang, MS, Lee, DH, Park, JE, Kim, DS, Lee, MW, Lee, JE, Jang, IK   +7 more
core   +1 more source