Results 21 to 30 of about 15,144 (118)

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

OncoImmunology, 2020
The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously targeting antigen and the solid tumor microenvironment are two major factors that greatly impact CAR ...
Baozhu Huang, Liqun Luo, Jun Wang, Bailin He, Rui Feng, Na Xian, Qiong Zhang, Lieping Chen, Gangxiong Huang   +8 more
doaj   +1 more source

Targeting the PD-1/PD-L1 Axis in Human Vitiligo

Frontiers in Immunology, 2020
Autoreactive CD8+ T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can ...
Marcella Willemsen, Cornelis J. M. Melief, Marcel W. Bekkenk, Rosalie M. Luiten   +3 more
doaj   +1 more source

Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells

Haematologica, 2013
Clinical trials of immunotherapy in mantle cell lymphoma have not yet delivered desirable results, partly because of the inhibitory machinery of the tumor and its microenvironment.
Lijuan Wang, Jianfei Qian, Yong Lu, Haiyan Li, Hanying Bao, Donghua He, Zhiqiang Liu, Yuhuan Zheng, Jin He, Yi Li, Sattva Neelapu, Jing Yang, Larry W. Kwak, Qing Yi, Zhen Cai   +14 more
doaj   +1 more source

Immunohistochemical Expression of Programmed Death Ligand-1 in Tumour Milieu of Oral Cancer

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2020
Objectives: To determine the immunohistochemical expression of PD-L1 in oral squamous cell carcinoma and to correlate it with clinicopathological parameters.
Moomal Aslam Khan, Serajuddaula Syed, Noor Ul Wahab, Saima Akram Butt   +3 more
doaj   +1 more source

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy [PDF]

Cancer Innov
Immunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Yaacoub K.
europepmc   +2 more sources

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Biomarker Research, 2020
Background On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors.
Qibin Liao, Yunyu Mao, Huan He, Xiangqing Ding, Xiaoyan Zhang, Jianqing Xu   +5 more
doaj   +1 more source

Pattern of differential expression of costimulatory molecules in myeloma cell line MM1.R

Revista Médica del Hospital General de México, 2018
T cells constantly recognise and eliminate circulating tumour cells. They require two signals in order to be activated: antigen presentation via TCR, and costimulatory interaction with different surface molecules of the B7 family, which may either ...
A. De la Cruz-Rosas, A. Martínez-Tovar, C. Ramos-Peñafiel, J. Collazo-Jaloma, I. Olarte-Carrillo   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

Specific zinc finger‐induced methylation of PD‐L1 promoter inhibits its expression

FEBS Open Bio, 2019
DNA methylation of promoter regions is often associated with epigenetic silencing of gene expression, and DNA methyltransferase (DNMTs) has been used to suppress gene expression.
Xue Li, Zhenni Wang, Jiansheng Huang, Huazao Luo, Sibo Zhu, Han Yi, Liuhai Zheng, Bo Hu, Lili Yu, Lingzhi Li, Jun Xie, Naishuo Zhu   +11 more
doaj   +1 more source

CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity

Frontiers in Immunology, 2019
Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs).
Dimitar B. Iliev, Dimitar B. Iliev, Leidy Lagos, Hanna L. Thim, Sven M. Jørgensen, Aleksei Krasnov, Jorunn B. Jørgensen   +6 more
doaj   +1 more source