Results 21 to 30 of about 545,026 (158)

Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro

OncoTargets and Therapy, 2014
The aim of this study was to examine whether short hairpin RNA (shRNA) expressing lentiviral particles targeting B7-H1 infection could result in B7-H1 knockdown on dendritic cells (DCs) and to investigate whether B7-H1 silencing could augment the immune function of DCs and further elicit a more potent anti-tumor immune effect against bladder cancer ...
Wang,Shuo, Wang,Yonghua, Liu,Jing, Shao,Shixiu, Li,Xianjun, Gao,Jiannan, Niu,Haitao, Wang,Xinsheng   +7 more
openaire   +4 more sources

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

Biomarker Research, 2020
Background On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors.
Qibin Liao, Yunyu Mao, Huan He, Xiangqing Ding, Xiaoyan Zhang, Jianqing Xu   +5 more
doaj   +1 more source

Pattern of differential expression of costimulatory molecules in myeloma cell line MM1.R

Revista Médica del Hospital General de México, 2018
T cells constantly recognise and eliminate circulating tumour cells. They require two signals in order to be activated: antigen presentation via TCR, and costimulatory interaction with different surface molecules of the B7 family, which may either ...
A. De la Cruz-Rosas, A. Martínez-Tovar, C. Ramos-Peñafiel, J. Collazo-Jaloma, I. Olarte-Carrillo   +4 more
doaj   +1 more source

CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS

Медицинская иммунология, 2014
. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors.
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Ostanin, E. R. Chernykh   +5 more
doaj   +1 more source

B7-H1 positive rate in clinical samples.

, 2017
B7-H1 positive rate in clinical samples.
Wei Li (7081), Ruidong Li (331648), Ke Wu (320733), Ende Zhao (3617516), Yuping Yin (3617510), Gengchen Xie (3617513), Yu Zhang (12946), Peng Zhang (2071), Liang Shi (8078), Rui Deng (157986), Kaixiong Tao (281715), Di Wang (329735)   +11 more
core   +1 more source

Specific zinc finger‐induced methylation of PD‐L1 promoter inhibits its expression

FEBS Open Bio, 2019
DNA methylation of promoter regions is often associated with epigenetic silencing of gene expression, and DNA methyltransferase (DNMTs) has been used to suppress gene expression.
Xue Li, Zhenni Wang, Jiansheng Huang, Huazao Luo, Sibo Zhu, Han Yi, Liuhai Zheng, Bo Hu, Lili Yu, Lingzhi Li, Jun Xie, Naishuo Zhu   +11 more
doaj   +1 more source

CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity

Frontiers in Immunology, 2019
Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs).
Dimitar B. Iliev, Dimitar B. Iliev, Leidy Lagos, Hanna L. Thim, Sven M. Jørgensen, Aleksei Krasnov, Jorunn B. Jørgensen   +6 more
doaj   +1 more source

B7-H1 levels in the HP-positive and HP-negative gastric cancer tissue samples.

, 2017
(A,B) HP+ and HP- gastric cancer tissue samples were double-immunostained with antibodies against Epcam (green) and B7-H1 (red). Hoechst staining (blue) was used to label the nuclei. (C) The ratio of B7-H1-positive cells to Epcam-positive cells in the HP+
Wei Li (7081), Ruidong Li (331648), Ke Wu (320733), Ende Zhao (3617516), Yuping Yin (3617510), Gengchen Xie (3617513), Yu Zhang (12946), Peng Zhang (2071), Liang Shi (8078), Rui Deng (157986), Kaixiong Tao (281715), Di Wang (329735)   +11 more
core   +1 more source

B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

, 2003
The ligation of programmed death-ligand 1 (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by ...
M. Clerici, P. Ferrante, G. M. Shearer, R. Maserati, M. Saresella, M. Biasin, L. Piacentini, L. Chen, D. Trabattoni, A. Boasso, H. Dong   +10 more
core   +1 more source

Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation [PDF]

, 2014
SummaryB7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dextran ...
Abadi, Yael M., Scandiuzzi, Lisa, Elaine Y. Lin, Jeon, Hyungjun, Hofmeyer, Kimberly A., Nathenson, Stanley G., Chen, Lieping, Xingxing Zang, Liu, Qiang, Hyungjun Jeon, Lisa Scandiuzzi, Almo, Steven C., Ghosh, Kaya, Kaya Ghosh, Lin, Elaine Y., Qiang Liu, Lieping Chen, Lázár-Molnár, Eszter, Yael M. Abadi, Eszter Lázár-Molnár, Steven C. Almo, Zang, Xingxing, Kimberly A. Hofmeyer, Stanley G. Nathenson   +23 more
core   +1 more source